The dorsal column pathway facilitates visceromotor responses to colorectal distention after colon inflammation in rats

0142476 - FGU-C 20030090 RIV NL eng J - Článek v odborném periodiku
Paleček, Jiří - Willis, W. D.
The dorsal column pathway facilitates visceromotor responses to colorectal distention after colon inflammation in rats.
Pain. Roč. 104, č. 3 (2003), s. 501-507. ISSN 0304-3959. E-ISSN 1872-6623
Grant CEP: GA ČR GA309/03/0752
Grant ostatní: NIH(US) NS 09743; NIH(US) NS 11255
Výzkumný záměr: CEZ:AV0Z5011922
Klíčová slova: visceral pain and visceral hyperalgesia * dorsal column * midline myelotomy
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
Impakt faktor: 4.556, rok: 2003

We examined the effect of bilateral dorsal columns (DC) or ventrolateral (VL) spinal cord lesions on viscemotor reflex EMG activity evoked by graded colorectal distention under control conditions and after colon inflammation with mustard oil. Our results suggest that the role of the DC pathway in transmission of visceral pain is augmented under inflammatory conditions when symptoms of visceral allodynia and hyperalgesia may be present. The VL lesions eliminated the viscemotor reflex, presumably by interrupting a facilitatory pathway that involves the brain stem.
Trvalý link: http://hdl.handle.net/11104/0040179