Počet záznamů: 1  

Report on the first patient group of the phase I BNCT trial at the LVR-15 reactor

  1. 1.
    0142357 - FGU-C 20020083 RIV IT eng C - Konferenční příspěvek (zahraniční konf.)
    Burian, J. - Marek, M. - Rataj, J. - Flibor, S. - Rejchrt, J. - Viererbl, L. - Sus, F. - Honová, H. - Petruzelka, L. - Prokes, K. - Tovarys, F. - Dbalý, V. - Beneš, V. - Kozler, P. - Honzátko, Jaroslav - Tomandl, Ivo - Mareš, Vladislav - Marek, J. - Syrucek, M.
    Report on the first patient group of the phase I BNCT trial at the LVR-15 reactor.
    Research and development in neutron capture therapy. Proceedings of the 10th International Congress on Neutron Capture Therapy. Bologna: Monduzzi Editore, 2002 - (Sauerwein, W.; Moss, R.; Wittig, A.), s. 1107-1112. ISBN 88-323-2909-3.
    [International Congress on Neutron Capture Therapy /10./. Essen (DE), 08.09.2002-13.09.2002]
    Grant CEP: GA ČR GV202/97/K038; GA MPO FD-K/048; GA MZd NC6473
    Výzkumný záměr: CEZ:AV0Z5011922
    Klíčová slova: neutron-capture-therapy * brain tumors * sodium borocaptate
    Kód oboru RIV: BG - Jaderná, atomová a mol. fyzika, urychlovače

    Clinical trials of Neutron Capture Therapy were initiated in some European countries including Czech Republic [1]. An epithermal neutron beam was constructed at the LVR-15 nuclear reactor at Řez near Prague. The phase I study of the Protocol approved by State Institute for Drug Control and State Office for Nuclear Safety of the Czech Republic has been used to define the limiting toxicity of the BNCT procedure. The group of 9 patients received BSH and underwent surgery, 5 patients were treated using BSH at the epithermal neutron facility of LVR-15 reactor in NRI Rez. No clinical deterioration of patients or laboratory data were observed during and after infusion of BSH, including normal kidney and liver functions. Immediately after the irradiation, in two patients there appeared nausea, vomiting or a grade II skin reaction in the irradiated area appeared within 3 weeks after the irradiation. One patient died in the first week after irradiation due to pulmonary embolism. In the remaining 4 irradiated patients signs of tumor growth progression appeared 2.5 to 6 months after irradiation.
    Trvalý link: http://hdl.handle.net/11104/0040063

     
     

Počet záznamů: 1  

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