Nitric oxide synthase inhibition and glutamate binding in quinolinate-lesioned rat hippocampus

0142337 - FGU-C 20020060 RIV CZ eng J - Článek v odborném periodiku
Lisý, Václav - Šťastný, František
Nitric oxide synthase inhibition and glutamate binding in quinolinate-lesioned rat hippocampus.
Physiological Research. Roč. 51, č. 3 (2002), s. 299-307. ISSN 0862-8408. E-ISSN 1802-9973
Grant CEP: GA ČR GA309/99/0211
Výzkumný záměr: CEZ:AV0Z5011922
Klíčová slova: quinolinic acid * NMDA receptor * membrane binding
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
Impakt faktor: 0.984, rok: 2002

The findings indicate that both the NMDA subtype of iGluR and group I of mGluR are susceptible to the QUIN-induced neurodegeneration in the rat hippocampus. The inhibition of NO synthesis does not reveal any protective action in the QUIN-evoked, NMDA-receptor mediated decrease of [(H]Glu membrane binding. Thus, the additional mechanisms of QUIN action, different from direct NMDA receptor activa-tion/NO production (e.g. lipid peroxidation induced by QUIN-Fe-complexex) cannot be excluded.
Trvalý link: http://hdl.handle.net/11104/0040043