Relative deficiency of nitric oxide-dependent vasodilation in salt hypertensive Dahl rats: the possible role of superoxide anions

0142122 - FGU-C 20010173 RIV US eng J - Článek v odborném periodiku
Zicha, Josef - Dobešová, Zdenka - Kuneš, Jaroslav
Relative deficiency of nitric oxide-dependent vasodilation in salt hypertensive Dahl rats: the possible role of superoxide anions.
Journal of Hypertension. Roč. 19, č. 2 (2001), s. 247-254. ISSN 0263-6352. E-ISSN 1473-5598
Grant CEP: GA AV ČR IAA7011805; GA AV ČR IAA7011711; GA MŠMT LN00A069
Výzkumný záměr: CEZ:AV0Z5011922
Klíčová slova: blood pressure * salt hypertension * Dahl rats
Kód oboru RIV: FA - Kardiovaskulární nemoci vč. kardiochirurgie
Impakt faktor: 4.210, rok: 2001

The contribution of major vasoactive systems (renin-angiotensin system, sympathetic nervous system and nitric oxide) to blood pressure maintenance and the possible involvement of superoxide anions in the reduced efficiency of NO-dependent vasodilation to counterbalance sympathetic vasoconstriction were studied in salt hypertensive Dahl rats. It was demonstrated that NO system is not able to counterbalance effectively the hyperactivity of sympathetic nervous system in salt hypertensive Dahl rats. The predominance of sympathetic vasoconstriction over NO-dependent vasodilation could partially be explained by enhanced NO inactivation due to augmented superoxide anion formation in hypertensive animals.
Trvalý link: http://hdl.handle.net/11104/0039831