Screening of the health risks of biofilms using a battery of in vitro toxicity assays

0129556 - BU-J 20020547 RIV CZ eng C - Konferenční příspěvek (zahraniční konf.)
Bláha, Luděk - Babica, P. - Sabatier, S. - Admiraal, W. - Maršálek, Blahoslav
Screening of the health risks of biofilms using a battery of in vitro toxicity assays.
SECOTOX 2002: Trends and advances in environmental chemistry and ecotoxicology. Brno: Masarykova univerzita, 2002, s. 150-154. ISBN 80-210-2971-4.
[Regional Meeting of the Central and Eastern European Section /7./. Brno (CZ), 14.10.2002-16.10.2002]
Grant CEP: GA AV ČR KSK6005114
Grant ostatní: BIOFILMS(XC) EVKI-CT-1999-00001
Výzkumný záměr: CEZ:AV0Z6005908
Klíčová slova: HCPL * microcystin
Kód oboru RIV: EF - Botanika

Traces of microcystin-lika compounds were detected by HPCL in biofilm samples from Netherlands. Half of the tested samples had no significant effect in any of the in vitro assays, other biofilms elicicted weak inhibitory/toxic effects mostly in high concentrations, which are not environmentally relevant. Most of observed weak effect seem to be associated with oxidative stress, an important toxicologicalĺmechanisms, as detected by depletion of intracellular antioxidantĺGHS by several biofilm samples. Potential adverse effects ofĺexterne polutants, which are known to accumulate in theĺperyphyton biomass should not underestimated. Mutagenicity andĺneurotoxicity of biofilm metabolits seems to be negligible. Weekĺadverse effects of biofilm extracts detected in a batery of inĺvitro assays indicate relatively low human health risksĺassociated with biofilm toxicity.
Trvalý link: http://hdl.handle.net/11104/0027734