0126931 - BFU-R 20033012 RIV SK eng J - Článek v odborném periodiku
Hoferová, Zuzana - Fedoročko, P. - Hofer, Michal - Hofmanová, Jiřina - Kozubík, Alois - Eliášová, V.
Lipoxygenase inhibitors suppress proliferation of G5:113 fibrosarcoma cells in vitro but they have no anticancer activity in vivo.
Neoplasma. Roč. 50, č. 2 (2003), s. 102-109. ISSN 0028-2685. E-ISSN 1338-4317
Grant CEP: GA AV ČR IBS5004009
Grant ostatní: VEGA MŠ SR(SK) 1/9211/02
Výzkumný záměr: CEZ:AV0Z5004920
Klíčová slova: fibrosarcoma * lipoxygenase inhibitors
Kód oboru RIV: BO - Biofyzika
Impakt faktor: 0.782, rok: 2003

Nordihydroguaiaretic acid (NDGA) and esculetin, both inhibitors of lipoxygenase, were found to suppress proliferation of murine G:5:113 fibrosarcoma cells in vitro. However, they had no curative effects in experiments in vivo when repeatedly administered to mice bearing tumours growing from subcutaneously transplanted G:5:113 cells. The results demonstrate the necessity of experiments in vivo for evaluating contingent anticancer effects of newly tested substances.

Trvalý link: http://hdl.handle.net/11104/0025158