Comparison of relative toxic potencies of hydroxylated PCBs and quinones in hepatic and mammary cell lines

0126892 - BFU-R 20023192 RIV ES eng C - Konferenční příspěvek (zahraniční konf.)
Machala, M. - Bláha, L. - Vondráček, Jan - Lehmler, H. J. - Robertson, L. W. - Malmberg, T.
Comparison of relative toxic potencies of hydroxylated PCBs and quinones in hepatic and mammary cell lines.
Organohalogen Compounds, vol. 56: Dioxin 2002. Barcelona, 2002 - (Rivera, J.; Llerena, J.; Abad, E.), s. 25-28. ISBN 84-607-5184-8.
[Dioxin 2002: International Symposium on Halogenated Environmental Organic Pollutants and POPs /22./. Barcelona (ES), 11.08.2002-16.08.2002]
Výzkumný záměr: CEZ:AV0Z5004920
Klíčová slova: hydroxylated PCBs * quinones * in vitro effects
Kód oboru RIV: BO - Biofyzika

A series of low-molecular-weight mono- and dihydroxylated PCBs (HO-PCBs), 2-(chlorophenyl)-1,4-benzoquinones (BQs) and 1,4-hydroquinones (HQs) were tested for their nongenotoxic potencies in several established in vitro cellular models. The data presented here show that both the low-molecular-weight PCB metabolites and the persistent HO-PCBs are capable of multiple nongenotoxic modes of action, including significant dioxin-like activity, modulation of ER-mediated activity and promotional effects associated with inhibition of intercellular communication.
Trvalý link: http://hdl.handle.net/11104/0025119