The 3D structure of human chromosomes in cell nuclei

0126871 - BFU-R 20023171 RIV NL eng J - Článek v odborném periodiku
Lukášová, Emilie - Kozubek, Stanislav - Kozubek, Michal - Falk, Martin - Amrichová, J.
The 3D structure of human chromosomes in cell nuclei.
Chromosome Research. Roč. 10, č. 7 (2002), s. 535-548. ISSN 0967-3849. E-ISSN 1573-6849
Grant CEP: GA AV ČR IBS5004010; GA AV ČR IAA1065203; GA MZd NC5955; GA ČR GA202/01/0197; GA ČR GA301/01/0186
Výzkumný záměr: CEZ:AV0Z5004920
Klíčová slova: confocal microscopy * mathematical models * chromosome structure
Kód oboru RIV: BO - Biofyzika
Impakt faktor: 1.828, rok: 2002

The structure of chromosome territory was studied in chromosomes containing clusters of highly expressed genes (HSA 9, 17) and those without such clustres (HSA 8, 13). It was found that the structure of chromosome territory reflects the number and chromosome location of highly expressed genes and that the nuclear distnces betwen genetic elements are not directly proportional to their molecular distances. A simple model of the chromosome territory tructure is proposed.
Trvalý link: http://hdl.handle.net/11104/0025098