Differential effects of v-Jun and c-Jun proteins on v-myb-transformed monoblasts

0126862 - BFU-R 20023162 RIV CH eng J - Článek v odborném periodiku
Ševčíková, S. - Souček, Karel - Kubala, Lukáš - Bryja, Vítězslav - Šmarda, J.
Differential effects of v-Jun and c-Jun proteins on v-myb-transformed monoblasts.
Cellular and Molecular Life Sciences. Roč. 59, č. 10 (2002), s. 1690-1705. ISSN 1420-682X. E-ISSN 1420-9071
Grant CEP: GA ČR GA301/01/0040
Výzkumný záměr: CEZ:AV0Z5004920
Klíčová slova: v-myb * Jun * differentiation
Kód oboru RIV: BO - Biofyzika
Impakt faktor: 5.259, rok: 2002

We ectopically expressed v-jun and c-jun in BM2 cells and evaluated their effects on differentiation and proliferation. c-Jun up-regulated the transactivation activity of v-Myb and induced a proliferation block and differentiation of BM2 cells. In contrast, v-Jun downregulated v-Myb transactivation causing no dramatic effects on BM2 cells. Both c-Jun and v-Jun proteins affected sensitivity of BM2 cells to retinoic acid and phorbol ster. These data suggest that Jun plays a major role in macrophage differentiation.
Trvalý link: http://hdl.handle.net/11104/0025089