Chromatin structure in solid cancers and leukemic cells

0126789 - BFU-R 20023088 RIV GB eng C - Konferenční příspěvek (zahraniční konf.)
Bártová, Eva - Kozubek, Stanislav - Jirsová, Pavla - Koutná, I. - Kozubek, Michal - Lukášová, Emilie - Skalníková, M. - Cafourková, Alena
Chromatin structure in solid cancers and leukemic cells.
QMC 2002: The Third Euroconference on Quantitative Molecular Cytogenetics. Manchester: European Commission, 2002 - (Graham, J.), s. 88-93
[QMC 2002: Euroconference on Quantitative Molecular Cytogenetics /3./. Stockholm (SE), 04.07.2002-06.07.2002]
Grant CEP: GA AV ČR IBS5004010; GA AV ČR IAB5004102; GA ČR GA301/01/0186
Klíčová slova: chromatin structure * chromosomal aberrations * retinoblastoma cells
Kód oboru RIV: BO - Biofyzika

Gene loci (Rb1, N-myc, p53) and chromosomes (6, 13, X and others) were studied in selected human tumour cells. Fresh tissue or paraffin-embedded sections were used for chromatin analyses. Heterogeneity in the copy number of genetic elements was found in tumour cells and lymphocytes of the patients with diagnosed retinoblastoma. Our findings support an assertion that structural and functional modifications of chromatin are an important feature of carcinogenesis.
Trvalý link: http://hdl.handle.net/11104/0025017