Nuclear structure and gene activity in human differentiated cells

0126775 - BFU-R 20023074 RIV US eng J - Článek v odborném periodiku
Bártová, Eva - Kozubek, Stanislav - Jirsová, Pavla - Kozubek, Michal - Gajová, H. - Lukášová, Emilie - Skalníková, M. - Cafourková, Alena - Koutná, I. - Hausmann, M.
Nuclear structure and gene activity in human differentiated cells.
Journal of Structural Biology. Roč. 139, č. 2 (2002), s. 76-89. ISSN 1047-8477. E-ISSN 1095-8657
Grant CEP: GA AV ČR IBS5004010; GA AV ČR IAB5004102; GA ČR GA301/01/0186
Výzkumný záměr: CEZ:AV0Z5004920
Klíčová slova: nuclear compartments * gene expression * FISH
Kód oboru RIV: BO - Biofyzika
Impakt faktor: 4.194, rok: 2002

The nuclear arrangement and activity of the ABL, c-MYC, and RB1 genes was quantitatively investigated in human undifferentiated HL-60 cells and in a terminally differentiated population of human granulocytes. In the experiments presented here, we provide evidence that the regulation of gene activity during important cellular processes such as differentiation or carcinogenesis may be realised through heterochromatin-mediated gene silencing.
Trvalý link: http://hdl.handle.net/11104/0025003