Modulation of death receptor-mediated apoptosis in differentiating human myeloid leukemia HL-60 cells

0126491 - BFU-R 20013051 RIV US eng J - Článek v odborném periodiku
Vondráček, Jan - Sheard, M. A. - Krejčí, P. - Minksová, Kateřina - Hofmanová, Jiřina - Kozubík, Alois
Modulation of death receptor-mediated apoptosis in differentiating human myeloid leukemia HL-60 cells.
Journal of Leukocyte Biology. Roč. 69, č. 5 (2001), s. 794-802. ISSN 0741-5400. E-ISSN 1938-3673
Grant CEP: GA ČR GA312/98/P011; GA ČR GA524/99/0694
Výzkumný záměr: CEZ:AV0Z5004920
Klíčová slova: all-trans retinoic acid * dimethyl sulfoxide
Kód oboru RIV: BO - Biofyzika
Impakt faktor: 4.516, rok: 2001

Cellular differentiation can play an important role in cell sensitivity to apoptotic stimuli. In the present study, effects of dimethyl sulfoxide (DMSO)- and all-trans retinoic acid (ATRA)-induced differentiation on tumor necrosis factor-alpha (TNF-alpha)- and anti-Fas-induced apoptosis in human myeloid leukemia cell line were studied. It was shown that DMSO potentiates, while ATRA blocks TNF-alpha and anti-Fas-induced apoptosis, in a time dependent manner
Trvalý link: http://hdl.handle.net/11104/0024719