Changes in the expression of FGFR3 in patients with chronic myeloid leukaemia receiving transplants of allogeneic peripheral blood stem cells

0126451 - BFU-R 20013011 RIV GB eng J - Článek v odborném periodiku
Dvořáková, D. - Krejčí, P. - Mayer, J. - Fajkus, Jiří - Hampl, Aleš - Dvořák, Petr
Changes in the expression of FGFR3 in patients with chronic myeloid leukaemia receiving transplants of allogeneic peripheral blood stem cells.
British Journal of Haematology. Roč. 113, č. 3 (2001), s. 832-835. ISSN 0007-1048. E-ISSN 1365-2141
Grant CEP: GA ČR GA312/97/0393; GA MŠMT ME 198
Výzkumný záměr: CEZ:AV0Z5045916
Klíčová slova: fibroblast growth factor receptor 3 * chronic myeloid leukaemia * stem cell transplantation
Kód oboru RIV: BO - Biofyzika
Impakt faktor: 2.815, rok: 2001

Patients suffering from CML express high levels of FGFR3 mRNA in white blood cells. After stem cell transplantation and reconstitution of haematopoiesis, the expression of FGFR3 decreased and was maintained at low levels that are typical of healthy individuals. FGFR3 expression became upregulated again in patients that had accelerated BCR/ABL rearrangement and underwent relapse of leukaemia
Trvalý link: http://hdl.handle.net/11104/0024680