Spatial arrangement of genes, centromeres and chromosomes in human blood cell nuclei and its changes during the cell cycle, differntiation and after irradiation

0126439 - BFU-R 20010259 RIV NL eng J - Článek v odborném periodiku
Skalníková, M. - Kozubek, Stanislav - Lukášová, Emilie - Bártová, Eva - Jirsová, Pavla - Cafourková, Alena - Koutná, I. - Kozubek, Michal
Spatial arrangement of genes, centromeres and chromosomes in human blood cell nuclei and its changes during the cell cycle, differntiation and after irradiation.
Chromosome Research. Roč. 8, - (2000), s. 487-499. ISSN 0967-3849. E-ISSN 1573-6849
Grant CEP: GA MŠMT VS97031; GA MZd NM15; GA AV ČR IBS5004010
Výzkumný záměr: CEZ:AV0Z5004920
Kód oboru RIV: BO - Biofyzika
Impakt faktor: 1.725, rok: 2000

The results show that different genetic loci (genes and centromeres) are located in specific subregions of cell nuclei which form distinct layers at defined centre-of-nucleus to locus distance. Some chromosomes are polarized with genes located in the inner parts of the nucleus and centromere on the nuclear periphery.
Trvalý link: http://hdl.handle.net/11104/0024669