Levels and Interactions of p27, Cyclin D3, and CDK4 During the Formation and Maintenance of the Corpus Luteum in Mice

0126376 - BFU-R 20000194 RIV US eng J - Článek v odborném periodiku
Hampl, A. - Pacherník, Jiří - Dvořák, P.
Levels and Interactions of p27, Cyclin D3, and CDK4 During the Formation and Maintenance of the Corpus Luteum in Mice.
Biology of Reproduction. Roč. 62, - (2000), s. 1393-1401. ISSN 0006-3363. E-ISSN 1529-7268
Grant CEP: GA MŠMT VS96115; GA ČR GV524/96/K162; GA ČR GA312/97/0393
Kód oboru RIV: EA - Morfologické obory a cytologie
Impakt faktor: 3.605, rok: 2000

For proper functioning of luteinizing/luteinized cells in vivo the cyclin-dependent kinase (CDK) inhibitor p27 is required. While inhibition of proliferation is underlaid by progressive lost of positive regulators of the cell cycle, including cyclins and CDK2, maintenance of the luteal phenotype is driven by up-regulated levels of p27 and cyclin D3, at least partially owing to formation of p27/cyclinD3/CDK4 trimers.
Trvalý link: http://hdl.handle.net/11104/0024606