Exact description of feedback ralationships in gene regulation systems

0105909 - URE-Y 20040064 SE eng A - Abstrakt
Šrobár, Fedor
Exact description of feedback ralationships in gene regulation systems.
Abstracts of the 5th International Conference on Biological Physics - ICBP 2004. Göteborg: Göteborgs Universitet, 2004. s. 79.
[Biological Physics /5./. 23.08.2004-27.08.2004, Göteborg]
Grant CEP: GA MŠMT OC 281.001
Výzkumný záměr: CEZ:AV0Z2067918
Klíčová slova: nonlinear systems
Kód oboru RIV: BO - Biofyzika

A genetic regulatory system consisting of a gene and activator and repressor proteins is investigated. The repressor competes with the activator for binding to gene's responsive elements. The kinetic equations for rates of change of concentrations of the above species are represented using the technique of causal diagrams. Presence of positive and negative feedback loop is apparent in the diagram topology. The qualitative behaviour is controlled by the sun of transmission functions of the two loops.
Trvalý link: http://hdl.handle.net/11104/0013097