Comprehensive Glycoscience: From Chemistry to Systems Biology

0095508 - MBÚ 2008 RIV SIGLE GB eng M - Část monografie knihy
Bojarová, Pavla - Křen, Vladimír
Enzymatic approaches to O-glycoside introduction: Glycosidases.
[Enzymatické metody zavedení O-glykosidu: Glykosidasy.]
Comprehensive Glycoscience: From Chemistry to Systems Biology. Oxford: Elsevier, 2007, s. 453-487. ISBN 978-0-444-51967-2
Grant CEP: GA MŠMT(CZ) LC06010; GA MŠMT OC 136; GA ČR GA203/05/0172; GA AV ČR IAA400200503
Výzkumný záměr: CEZ:AV0Z50200510
Klíčová slova: glycosidases * o-glycosidic linkages
Kód oboru RIV: CC - Organická chemie

This chapter describes the formation of O-glycosidic linkages under the catalysis by glycosidases. A wide range of examples demonstrate the broad synthetic potential of these enzymes both on the laboratory and industrial scales. The molecular principles of all glycosidase-catalyzed reaction types is explained. The authors present diverse glycosyl donors and acceptors and discuss their viability in the synthesis by glycosidases. A special attention is devoted to the use of modified substrates, which enable to introduce other functional moieties in glycostructures. The basic features of glycosidase regioselectivity are specified with respect to the reaction design, mainly to the choice of substrates and the enzyme source

Kapitola popisuje syntézu O-glykosidické vazby pomocí glykosidas. Široká škála příkladů demonstruje široký aplikační potenciál těchto enzymů jak v laboratorní, tak i v průmyslové oblasti
Trvalý link: http://hdl.handle.net/11104/0155081