Počet záznamů: 1  

Synthesis and cytotoxic activity of substituted 2-phenyl-3-hydroxy-4(1H)-quinolinones-7-carboxylic acids and their phenacyl esters

  1. 1.
    0083355 - ÚEB 2007 RIV FR eng J - Článek v odborném periodiku
    Soural, M. - Hlaváč, J. - Hradil, P. - Fryšová, I. - Hajdúch, M. - Bertolasi, V. - Maloň, Michal
    Synthesis and cytotoxic activity of substituted 2-phenyl-3-hydroxy-4(1H)-quinolinones-7-carboxylic acids and their phenacyl esters.
    [Synthesis and cytotoxic activity of substituted 2-phenyl-3-hydroxy-4(1H)-quinolinones-7-carboxylic acids and their phenacyl esters.]
    European Journal of Medicinal Chemistry. Roč. 41, č. 4 (2006), s. 467-474. ISSN 0223-5234. E-ISSN 1768-3254
    Výzkumný záměr: CEZ:AV0Z50380511
    Klíčová slova: Quinolinone * Cytotoxic activity * X-ray structure
    Kód oboru RIV: CE - Biochemie
    Impakt faktor: 2.187, rok: 2006

    The preparation of 3-hydroxy-2-phenyl-4(1H)-quinolinones substituted in position 7 with a carboxyl group is described. The synthesis is based on the reaction of 2-aminoterephthalic acid with substituted α-bromoacetophenones and subsequent cyclization of the resulting bisphenacylesters in polyphosphoric acid. The reaction affords a mixture of substituted 3-hydroxy-2-phenyl-4(1H)-quinolinones 7-carboxylic acids as well as their phenacylesters. All quinolinones prepared (acids and phenacylesters) were tested for cytotoxic activity in vitro against five cancer cell lines and the results and a tentative structure–activity relationship are reported.

    Synthesis and cytotoxic activity of substituted 2-phenyl-3-hydroxy-4(1H)-quinolinones-7-carboxylic acids and their phenacyl esters.
    Trvalý link: http://hdl.handle.net/11104/0146620

     
     
Počet záznamů: 1  

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