Effect of haloperidol on transient outward potassium current in rat ventricular myocytes

0042934 - ÚT 2007 RIV NL eng J - Článek v odborném periodiku
Bébarová, M. - Matejovič, P. - Pásek, Michal - Nováková, M.
Effect of haloperidol on transient outward potassium current in rat ventricular myocytes.
[Účinek haloperidolu na přechodný draslíkový proud u komorových buněk potkana.]
European Journal of Pharmacology. Roč. 550, - (2006), s. 15-23. ISSN 0014-2999. E-ISSN 1879-0712
Grant CEP: GA ČR(CZ) GA305/04/1385
Výzkumný záměr: CEZ:AV0Z20760514
Klíčová slova: rat ventricular myocytes * transient outward current * haloperidol * whole-cell patch clamp
Kód oboru RIV: BO - Biofyzika
Impakt faktor: 2.522, rok: 2006

Although sigma ligand haloperidol is known to affect repolarization in heart, its effect on potassium currents in cardiomyocytes has not yet been studied. We analyzed the effect of 1 /mi/mol/l haloperidol on transient outward K+ current (Ito) in enzymatically isolated rat right ventricular cardiomyocytes using the whole-cell patch-clamp technique at room temperature. Haloperidol induced a decrease of amplitude and an acceleration of apparent inactivation of Ito, both in a voltage-independent manner. The averaged inhibition of Ito, evaluated as a change of its time integral, was 23.0+/-3.2% at stimulation frequency of 0.1 Hz. As a consequence of slow recovery of Ito from the haloperidol-induced block (time constant 1482+/- 783 ms), a cumulation of the block up to about 40% appeared at 3.3 Hz.We conclude that haloperidol causes a voltage-independent block of Ito that cumulates at higher stimulation frequencies.

Práce popisuje účinek psychofarmaka haloperidolu na přechodný draslíkový proud u srdečních komorových buněk potkana a představuje matematický model interakce látky s příslušnými draslíkovými kanály v buněčné membráně.
Trvalý link: http://hdl.handle.net/11104/0136060