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Melanoma-Bearing Libechov Minipig (MeLiM): The Unique Swine Model of Hereditary Metastatic Melanoma

SYSNO ASEP	0518790
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Melanoma-Bearing Libechov Minipig (MeLiM): The Unique Swine Model of Hereditary Metastatic Melanoma
Tvůrce(i)	Horák, Vratislav (UZFG-Y)_{RID, ORCID} Palánová, Anna (UZFG-Y)_{RID, ORCID} Čížková, Jana (UZFG-Y) Miltrová, Veronika (UZFG-Y) Vodička, Petr (UZFG-Y)_ORCID Kupcová Skalníková, Helena (UZFG-Y)_{RID, ORCID}
Číslo článku	915
Zdroj.dok.	Genes. - : MDPI Roč. 10, č. 11 (2019)
Poč.str.	34 s.
Forma vydání	Online - E
Jazyk dok.	eng - angličtina
Země vyd.	CH - Švýcarsko
Klíč. slova	melanoma ; mutation ; genetics
Vědní obor RIV	GJ - Choroby a škůdci zvířat, veterinární medicína
Obor OECD	Veterinary science
CEP	LO1609 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
	EF16_019/0000785 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
Způsob publikování	Open access
Institucionální podpora	UZFG-Y - RVO:67985904
UT WOS	000502296000081
EID SCOPUS	85074789445
DOI	10.3390/genes10110915
Anotace	National cancer databases document that melanoma is the most aggressive and deadly cutaneous malignancy with worldwide increasing incidence in the Caucasian population. Around 10% of melanomas occur in families. Several germline mutations were identified that might help to indicate individuals at risk for preventive interventions and early disease detection. More than 50% of sporadic melanomas carry mutations in Ras/Raf/mitogen-activated protein kinase (MAPK/MEK) pathway, which may represent aims of novel targeted therapies. Despite advances in targeted therapies and immunotherapies, the outcomes in metastatic tumor are still unsatisfactory. Here, we review animal models that help our understanding of melanoma development and treatment, including non-vertebrate, mouse, swine, and other mammal models, with an emphasis on those with spontaneously developing melanoma. Special attention is paid to the melanoma-bearing Libechov minipig (MeLiM). This original swine model of hereditary metastatic melanoma enables studying biological processes underlying melanoma progression, as well as spontaneous regression. Current histological, immunohistochemical, biochemical, genetic, hematological, immunological, and skin microbiome findings in the MeLiM model are summarized, together with development of new therapeutic approaches based on tumor devitalization. The ongoing study of molecular and immunological base of spontaneous regression in MeLiM model has potential to bring new knowledge of clinical importance.
Pracoviště	Ústav živočišné fyziologie a genetiky
Kontakt	Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554
Rok sběru	2020
Elektronická adresa	https://www.mdpi.com/2073-4425/10/11/915

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