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Human gut microbes are susceptible to antimicrobial food additives in vitro
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SYSNO ASEP 0507936 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Human gut microbes are susceptible to antimicrobial food additives in vitro Tvůrce(i) Hrnčířová, Lucia (MBU-M)
Hudcovic, Tomáš (MBU-M) RID, ORCID
Suková, Eliška (MBU-M)
Machová, Vladimíra (MBU-M)
Trčková, Eva (MBU-M)
Krejsek, J. (CZ)
Hrnčíř, Tomáš (MBU-M) RID, ORCIDZdroj.dok. Folia Microbiologica. - : Springer - ISSN 0015-5632
Roč. 64, č. 4 (2019), s. 497-508Poč.str. 12 s. Jazyk dok. eng - angličtina Země vyd. CZ - Česká republika Klíč. slova Gut microbiota ; Autoimmune diseases ; Dysbiosis Vědní obor RIV EE - Mikrobiologie, virologie Obor OECD Microbiology CEP GA15-09518S GA ČR - Grantová agentura ČR GA15-07268S GA ČR - Grantová agentura ČR NV17-31248A GA MZd - Ministerstvo zdravotnictví Způsob publikování Omezený přístup Institucionální podpora MBU-M - RVO:61388971 UT WOS 000475800500003 EID SCOPUS 85060231414 DOI 10.1007/s12223-018-00674-z Anotace The aim of this work was to test the hypothesis that antimicrobial food additives may alter the composition of human gut microbiota by selectively suppressing the growth of susceptible gut microbes. To explore the influence of antimicrobial food additives on the composition of the human gut microbiota, we examined the susceptibility of both aerobic and anaerobic gut bacteria to sodium benzoate, sodium nitrite, and potassium sorbate, and their combinations, using a broth microdilution method. The tested bacteria exhibited a wide range of susceptibilities to food additives. For example, the most susceptible strain, Bacteroides coprocola, was almost 580 times more susceptible to sodium nitrite than the most resistant strain, Enterococcus faecalis. However, most importantly, we found that gut microbes with known anti-inflammatory properties, such as Clostridium tyrobutyricum or Lactobacillus paracasei, were significantly more susceptible to additives than microbes with known proinflammatory or colitogenic properties, such as Bacteroides thetaiotaomicron or Enterococcus faecalis. Our data show that some human gut microbes are highly susceptible to antimicrobial food additives. We speculate that permanent exposure of human gut microbiota to even low levels of additives may modify the composition and function of gut microbiota and thus influence the host's immune system. Whether the effect of additive-modified gut microbiota on the human immune system could explain, at least in part, the increasing incidence of allergies and autoimmune diseases remains to be shown. Pracoviště Mikrobiologický ústav Kontakt Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Rok sběru 2020 Elektronická adresa https://link.springer.com/article/10.1007%2Fs12223-018-00674-z
Počet záznamů: 1