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Poor chemical and microbiological quality of the commercial milk thistle-based dietary supplements may account for their reported unsatisfactory and non-reproducible clinical outcomes
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SYSNO ASEP 0507890 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Poor chemical and microbiological quality of the commercial milk thistle-based dietary supplements may account for their reported unsatisfactory and non-reproducible clinical outcomes Tvůrce(i) Fenclová, M. (CZ)
Nováková, A. (CZ)
Viktorová, J. (CZ)
Jonatová, P. (CZ)
Džuman, Z. (CZ)
Ruml, T. (CZ)
Křen, Vladimír (MBU-M) RID, ORCID
Hajslová, J. (CZ)
Vítek, L. (CZ)
Stránská Zachariášová, M. (CZ)Číslo článku 11118 Zdroj.dok. Scientific Reports. - : Nature Publishing Group - ISSN 2045-2322
Roč. 9, JUL 31 (2019)Poč.str. 12 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova chronic hepatitis-c ; pyrrolizidine alkaloids ; silybum-marianum Vědní obor RIV FE - Ostatní obory vnitřního lékařství Obor OECD Nutrition, Dietetics CEP GA18-00150S GA ČR - Grantová agentura ČR NV16-27317A GA MZd - Ministerstvo zdravotnictví Způsob publikování Open access Institucionální podpora MBU-M - RVO:61388971 UT WOS 000477950800041 EID SCOPUS 85070885163 DOI 10.1038/s41598-019-47250-0 Anotace Herbal-based dietary supplements have become increasingly popular. The extract from milk thistle (Silybum marianum), is often used for the treatment of liver diseases. However, serious concerns exist regarding the efficacy, composition, as well as the safety of these over-the-counter preparations. Therefore, the aim of the present study was to investigate the composition as well as chemical and biological safety of 26 milk thistle-based dietary supplements purchased from both the U.S. and Czech markets between 2016 and 2017. The study was focused on a determination of the composition of active ingredients, as well as analyses of possible contaminants including: mycotoxins, plant alkaloids, and pesticide residues, as well as the microbial purity. High-throughput analyses were performed using advanced U-HPLC-HRMS techniques. Large differences in the silymarin content were observed among individual milk thistle preparations, often in contrast with the information provided by the manufacturers. In addition, substantial inter-batch differences in silymarin content were also demonstrated. In all milk thistle preparations tested, large numbers and high concentrations of mycotoxins and several pesticides, as well as the substantial presence of microbiological contamination were detected, pointing to serious safety issues. In conclusion, our results strongly indicate the need for strict controls of the composition, chemical contaminants, as well as the microbiological purity of commercial milk thistle extracts used for the treatment of liver diseases. Poor definition of these preparations together with contamination by biologically active substances may not only account for the inconsistency of clinical observations, but also be responsible for possible herbal-based dietary supplements-induced liver injury. Pracoviště Mikrobiologický ústav Kontakt Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Rok sběru 2020 Elektronická adresa https://www.nature.com/articles/s41598-019-47250-0
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