Počet záznamů: 1
Interval estimation of congenital anomaly risk in twins
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SYSNO ASEP 0506822 Druh ASEP A - Abstrakt Zařazení RIV O - Ostatní Název Interval estimation of congenital anomaly risk in twins Tvůrce(i) Klaschka, Jan (UIVT-O) RID, SAI, ORCID
Malý, Marek (UIVT-O) RID, SAI
Šípek, A. (CZ)Zdroj.dok. 40th Annual Conference of the International Society for Clinical Biostatistics. Book of abstracts. - Leuven : ISCB, 2019 - ISBN 978-94-6165-287-4
S. 366-367Poč.str. 2 s. Forma vydání Online - E Akce Annual Conference of the International Society for Clinical Biostatistics /40./ Datum konání 14.07.2019 - 18.07.2019 Místo konání Leuven Země BE - Belgie Typ akce WRD Jazyk dok. eng - angličtina Země vyd. BE - Belgie Klíč. slova interval estimate ; congenital anomalies ; twins Vědní obor RIV BB - Aplikovaná statistika, operační výzkum Obor OECD Statistics and probability CEP NV17-29622A GA MZd - Ministerstvo zdravotnictví Institucionální podpora UIVT-O - RVO:67985807 Anotace IN: 40th Annual Conference of the International Society for Clinical Biostatistics. Book of abstracts. Leuven: ISCB, 2019. s. 364-365. ISBN 978-94-6165-287-4. [Annual Conference of the International Society for Clinical Biostatistics /40./. 14.07.2019-18.07.2019, Leuven]. ABSTRACT: In a medical research project, we analyze data of several Czech national health registries in order to assess prevalence of different kinds of congenital anomalies (birth defects). The risk of birth defect in twins is known to differ from that in the children from single pregnancies, and dependence between the twins should be considered, especially in the field of testing and interval estimation. Objectives: Under the assumptions of equal birth defect risk for all children born as twins, and equal phi coefficient (as a measure of dependence) for all twin pairs, we have derived and programmed interval estimates of the risk from twin data. The confidence interval types dealt with are asymptotic Wald (normal approximation), and exact Clopper-Pearson (twice the smaller tail), and Blaker (combined tails). Two different situations are studied: Either the information which pairs of twins belong together is available, or not (which is the case in our project). In the former situation, the phi coefficient may be estimated, while in the latter one we only have to rely on external estimates, or the conclusions drawn must be conditional on the phi value. Methods: While the Wald type confidence bounds are given as closed-form expressions, the exact confidence intervals are calculated numerically. One of the key steps of the numerical procedure is the calculation of the probability mass function of the number of events by a numerical inversion of the characteristic function Pracoviště Ústav informatiky Kontakt Tereza Šírová, sirova@cs.cas.cz, Tel.: 266 053 800 Rok sběru 2020
Počet záznamů: 1