Počet záznamů: 1  

Successful surgical excision of cerebral abscess caused by Fonsecaea monophora in an immunocompetent patient and review of literature

  1. 1.
    SYSNO ASEP0505492
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    Poddruh JČlánek ve WOS
    NázevSuccessful surgical excision of cerebral abscess caused by Fonsecaea monophora in an immunocompetent patient and review of literature
    Tvůrce(i) Dobiáš, R. (CZ)
    Filip, M. (CZ)
    Vrágová, K. (CZ)
    Dolinská, D. (CZ)
    Závodná, P. (CZ)
    Dujka, A. (CZ)
    Linzer, P. (CZ)
    Jurek, P. (CZ)
    Studená, B. (CZ)
    Černá, E. (CZ)
    Mrázek, J. (CZ)
    Jaworská, P. (CZ)
    Kantorová, M. (CZ)
    Lysková, P. (CZ)
    Krejčí, E. (CZ)
    Hubka, Vít (MBU-M) ORCID
    Zdroj.dok.Folia Microbiologica. - : Springer - ISSN 0015-5632
    Roč. 64, č. 3 (2019), s. 383-388
    Poč.str.6 s.
    Jazyk dok.eng - angličtina
    Země vyd.CZ - Česká republika
    Klíč. slovapheohyphomycosis ; voriconazole
    Vědní obor RIVEE - Mikrobiologie, virologie
    Obor OECDMicrobiology
    CEPED1.1.00/02.0109 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
    Způsob publikováníOmezený přístup
    Institucionální podporaMBU-M - RVO:61388971
    UT WOS000468847600010
    EID SCOPUS85055705159
    DOI10.1007/s12223-018-0661-9
    AnotaceCerebral abscesses caused by dark-pigmented Fonsecaea fungi are rare, especially in otherwise healthy individuals. In this case report, we present a 61-year-old man from Moldova, living in the Czech Republic, who had worked as a locksmith on oil platforms in Turkmenistan, Kazakhstan, Sudan, and Iraq since 1999, and was admitted to a neurology ward for a sudden motion disorder of the right leg, dysarthria, and hypomimia. Imaging revealed presence of expansive focus around the left lateral ventricle of the brain and a pronounced peripheral edema. The intracranial infectious focus was excised under intraoperative SonoWand guidance. Tissue samples were histologically positive for dark-pigmented hyphae, suggesting dematiaceous fungi. Therefore, liposomal amphotericin B therapy was initiated immediately. Fonsecaea monophora was provisionally identified using ITS rDNA region sequencing directly from brain tissue. The identification was subsequently confirmed by cultivation and DNA sequencing from culture. The strain exhibited in vitro sensitive to voriconazole (MIC=0.016g/mL) and resistance to amphotericin B (MIC=4g/mL), therefore, the amphotericin B was replaced with voriconazole. Postoperatively, a significant clinical improvement was observed and no additional surgery was required. Based on the literature review, this is the third documented case of cerebral infection due to this pathogen in patients without underlying conditions and the first such case in Europe.
    PracovištěMikrobiologický ústav
    KontaktEliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231
    Rok sběru2020
    Elektronická adresahttps://link.springer.com/article/10.1007%2Fs12223-018-0661-9
Počet záznamů: 1  

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