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Successful surgical excision of cerebral abscess caused by Fonsecaea monophora in an immunocompetent patient and review of literature
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SYSNO ASEP 0505492 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Successful surgical excision of cerebral abscess caused by Fonsecaea monophora in an immunocompetent patient and review of literature Tvůrce(i) Dobiáš, R. (CZ)
Filip, M. (CZ)
Vrágová, K. (CZ)
Dolinská, D. (CZ)
Závodná, P. (CZ)
Dujka, A. (CZ)
Linzer, P. (CZ)
Jurek, P. (CZ)
Studená, B. (CZ)
Černá, E. (CZ)
Mrázek, J. (CZ)
Jaworská, P. (CZ)
Kantorová, M. (CZ)
Lysková, P. (CZ)
Krejčí, E. (CZ)
Hubka, Vít (MBU-M) ORCIDZdroj.dok. Folia Microbiologica. - : Springer - ISSN 0015-5632
Roč. 64, č. 3 (2019), s. 383-388Poč.str. 6 s. Jazyk dok. eng - angličtina Země vyd. CZ - Česká republika Klíč. slova pheohyphomycosis ; voriconazole Vědní obor RIV EE - Mikrobiologie, virologie Obor OECD Microbiology CEP ED1.1.00/02.0109 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Omezený přístup Institucionální podpora MBU-M - RVO:61388971 UT WOS 000468847600010 EID SCOPUS 85055705159 DOI 10.1007/s12223-018-0661-9 Anotace Cerebral abscesses caused by dark-pigmented Fonsecaea fungi are rare, especially in otherwise healthy individuals. In this case report, we present a 61-year-old man from Moldova, living in the Czech Republic, who had worked as a locksmith on oil platforms in Turkmenistan, Kazakhstan, Sudan, and Iraq since 1999, and was admitted to a neurology ward for a sudden motion disorder of the right leg, dysarthria, and hypomimia. Imaging revealed presence of expansive focus around the left lateral ventricle of the brain and a pronounced peripheral edema. The intracranial infectious focus was excised under intraoperative SonoWand guidance. Tissue samples were histologically positive for dark-pigmented hyphae, suggesting dematiaceous fungi. Therefore, liposomal amphotericin B therapy was initiated immediately. Fonsecaea monophora was provisionally identified using ITS rDNA region sequencing directly from brain tissue. The identification was subsequently confirmed by cultivation and DNA sequencing from culture. The strain exhibited in vitro sensitive to voriconazole (MIC=0.016g/mL) and resistance to amphotericin B (MIC=4g/mL), therefore, the amphotericin B was replaced with voriconazole. Postoperatively, a significant clinical improvement was observed and no additional surgery was required. Based on the literature review, this is the third documented case of cerebral infection due to this pathogen in patients without underlying conditions and the first such case in Europe. Pracoviště Mikrobiologický ústav Kontakt Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Rok sběru 2020 Elektronická adresa https://link.springer.com/article/10.1007%2Fs12223-018-0661-9
Počet záznamů: 1