Počet záznamů: 1
Dietary Polyphenols Targeting Arterial Stiffness: Interplay of Contributing Mechanisms and Gut Microbiome-Related Metabolism
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SYSNO ASEP 0504552 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Dietary Polyphenols Targeting Arterial Stiffness: Interplay of Contributing Mechanisms and Gut Microbiome-Related Metabolism Tvůrce(i) De Bruyne, T. (BE)
Steenput, B. (BE)
Roth, L. (BE)
De Meyer, G.R.Y. (BE)
Nunes dos Santos, C. (PT)
Valentová, Kateřina (MBU-M) RID, ORCID
Dambrova, M . (LT)
Hermans, N. (BE)Číslo článku 578 Zdroj.dok. Nutrients. - : MDPI
Roč. 11, č. 3 (2019)Poč.str. 43 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova arterial stiffness ; polyphenols ; polyphenol biotransformation Vědní obor RIV FA - Kardiovaskulární nemoci vč. kardiochirurgie Obor OECD Cardiac and Cardiovascular systems CEP GA18-00121S GA ČR - Grantová agentura ČR LTC18003 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Open access Institucionální podpora MBU-M - RVO:61388971 UT WOS 000464376300004 EID SCOPUS 85062854208 DOI 10.3390/nu11030578 Anotace Increased arterial stiffness is a degenerative vascular process, progressing with age that leads to a reduced capability of arteries to expand and contract in response to pressure changes. This progressive degeneration mainly affects the extracellular matrix of elastic arteries and causes loss of vascular elasticity. Recent studies point to significant interference of dietary polyphenols with mechanisms involved in the pathophysiology and progression of arterial stiffness. This review summarizes data from epidemiological and interventional studies on the effect of polyphenols on vascular stiffness as an illustration of current research and addresses possible etiological factors targeted by polyphenols, including pathways of vascular functionality, oxidative status, inflammation, glycation, and autophagy. Effects can either be inflicted directly by the dietary polyphenols or indirectly by metabolites originated from the host or microbial metabolic processes. The composition of the gut microbiome, therefore, determines the resulting metabolome and, as a consequence, the observed activity. On the other hand, polyphenols also influence the intestinal microbial composition, and therefore the metabolites available for interaction with relevant targets. As such, targeting the gut microbiome is another potential treatment option for arterial stiffness. Pracoviště Mikrobiologický ústav Kontakt Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Rok sběru 2020 Elektronická adresa https://www.mdpi.com/2072-6643/11/3/578
Počet záznamů: 1