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Increased Expression of Maturation Promoting Factor Components Speeds Up Meiosis in Oocytes from Aged Females
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SYSNO ASEP 0504101 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Increased Expression of Maturation Promoting Factor Components Speeds Up Meiosis in Oocytes from Aged Females Tvůrce(i) Končická, Markéta (UZFG-Y) ORCID
Tětková, Anna (UZFG-Y) ORCID
Jansová, Denisa (UZFG-Y) ORCID
del Llano, Edgar (UZFG-Y) ORCID
Gahurová, Lenka (UZFG-Y) ORCID
Kračmarová, J. (CZ)
Prokešová, Š. (CZ)
Mašek, T. (CZ)
Pospíšek, M. (CZ)
Bruce, A. W. (CZ)
Kubelka, Michal (UZFG-Y) RID, ORCID
Šušor, Andrej (UZFG-Y) RID, ORCIDČíslo článku 2841 Zdroj.dok. International Journal of Molecular Sciences. - : MDPI
Roč. 19, č. 9 (2018)Poč.str. 17 s. Forma vydání Online - E Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova aging ; oocyte ; MPF Vědní obor RIV EB - Genetika a molekulární biologie Obor OECD Reproductive biology (medical aspects to be 3) CEP EF15_003/0000460 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy GA18-19395S GA ČR - Grantová agentura ČR GA15-22765S GA ČR - Grantová agentura ČR Způsob publikování Open access Institucionální podpora UZFG-Y - RVO:67985904 UT WOS 000449988100377 EID SCOPUS 85053720417 DOI 10.3390/ijms19092841 Anotace The rate of chromosome segregation errors that emerge during meiosis I in the mammalian female germ line are known to increase with maternal age, however, little is known about the underlying molecular mechanism. The objective of this study was to analyze meiotic progression of mouse oocytes in relation to maternal age. Using the mouse as a model system, we analyzed the timing of nuclear envelope breakdown and the morphology of the nuclear lamina of oocytes obtained from young (2 months old) and aged females (12 months old). Oocytes obtained from older females display a significantly faster progression through meiosis I compared to the ones obtained from younger females. Furthermore, in oocytes from aged females, lamin A/C structures exhibit rapid phosphorylation and dissociation. Additionally, we also found an increased abundance of MPF components and increased translation of factors controlling translational activity in the oocytes of aged females. In conclusion, the elevated MPF activity observed in aged female oocytes affects precocious meiotic processes that can multifactorially contribute to chromosomal errors in meiosis I. Pracoviště Ústav živočišné fyziologie a genetiky Kontakt Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554 Rok sběru 2020 Elektronická adresa https://www.mdpi.com/1422-0067/19/9/2841
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