Počet záznamů: 1
Fibroblast growth factor receptor influences primary cilium length through an interaction with intestinal cell kinase
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SYSNO ASEP 0504030 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Fibroblast growth factor receptor influences primary cilium length through an interaction with intestinal cell kinase Tvůrce(i) Kunová Bosáková, M. (CZ)
Nita, A. (CZ)
Gregor, T. (CZ)
Vařecha, M. (CZ)
Gudernová, I. (CZ)
Fafílek, B. (CZ)
Bárta, T. (CZ)
Basheer, N. (CZ)
Abraham, S. P. (CZ)
Bálek, L. (CZ)
Tomanová, M. (CZ)
Fialová Kučerová, J. (CZ)
Bosák, J. (CZ)
Potěšil, D. (CZ)
Zieba, J. T. (US)
Song, J. S. (KR)
Koník, P. (CZ)
Park, S. (US)
Duran, I. (US)
Zdráhal, Z. (CZ)
Šmajs, D. (CZ)
Jansen, G. (NL)
Fu, Z. (CN)
Wan Ko, H. (KR)
Hampl, A. (CZ)
Trantírek, L. (CZ)
Krakow, D. (US)
Krejčí, Pavel (UZFG-Y) ORCIDZdroj.dok. Proceedings of the National Academy of Sciences of the United States of America. - : National Academy of Sciences - ISSN 0027-8424
Roč. 116, č. 10 (2019), s. 4316-4325Poč.str. 10 s. Forma vydání Tištěná - P Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova fibroblast growth factor ; intestinal cell kinase ; cilia lenght Vědní obor RIV EB - Genetika a molekulární biologie Obor OECD Biochemistry and molecular biology Způsob publikování Open access Institucionální podpora UZFG-Y - RVO:67985904 UT WOS 000460242100061 EID SCOPUS 85062661279 DOI 10.1073/pnas.1800338116 Anotace Vertebrate primary cilium is a Hedgehog signaling center but the extent of its involvement in other signaling systems is less well understood. This report delineates a mechanism by which fibroblast growth factor (FGF) controls primary cilia. Employing proteomic approaches to characterize proteins associated with the FGF-receptor, FGFR3, we identified the serine/threonine kinase intestinal cell kinase (ICK) as an FGFR interactor. ICK is involved in ciliogenesis and participates in control of ciliary length. FGF signaling partially abolished ICK's kinase activity, through FGFR-mediated ICK phosphorylation at conserved residue Tyr15, which interfered with optimal ATP binding. Activation of the FGF signaling pathway affected both primary cilia length and function in a manner consistent with cilia effects caused by inhibition of ICK activity. Moreover, knockdown and knockout of ICK rescued the FGF-mediated effect on cilia. We provide conclusive evidence that FGF signaling controls cilia via interaction with ICK. Pracoviště Ústav živočišné fyziologie a genetiky Kontakt Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554 Rok sběru 2020 Elektronická adresa https://www.pnas.org/content/116/10/4316
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