Počet záznamů: 1
Revitalising the rudimentary replacement dentition in the mouse
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SYSNO ASEP 0503702 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Revitalising the rudimentary replacement dentition in the mouse Tvůrce(i) Popa, E. M. (GB)
Buchtová, Marcela (UZFG-Y) RID, ORCID
Tucker, Abigail (UEM-P)Číslo článku UNSP dev171363 Zdroj.dok. Development. - : Company of Biologists - ISSN 0950-1991
Roč. 146, č. 3 (2019)Poč.str. 11 s. Forma vydání Online - E Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova replacement tooth ; Wnt/beta-catenin ; Sox2 Vědní obor RIV EB - Genetika a molekulární biologie Obor OECD Developmental biology CEP GA18-04859S GA ČR - Grantová agentura ČR EF15_003/0000460 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Open access Institucionální podpora UZFG-Y - RVO:67985904 ; UEM-P - RVO:68378041 UT WOS 000458841100014 EID SCOPUS 85061226297 DOI 10.1242/dev.171363 Anotace Most mammals have two sets of teeth (diphyodont) - a deciduous dentition replaced by a permanent dentition, however, the mouse possesses only one tooth generation (monophyodont). In diphyodonts, the replacement tooth forms on the lingual side of the first tooth from the successional dental lamina. This lamina expresses the stem/progenitor marker Sox2 and has activated Wnt/beta-catenin signalling at its tip. Although the mouse does not replace its teeth, a transient rudimentary successional dental lamina (RSDL) still forms during development. The mouse RSDL houses Sox2-positive cells, but no Wnt/beta-catenin signalling. Here, we show that stabilising Wnt/beta-catenin signalling in the RSDL in the mouse leads to proliferation of the RSDL and formation of lingually positioned teeth. Although Sox2 has been shown to repress Wnt activity, overexpression of Wnts leads to a downregulation of Sox2, suggesting a negative-feedback loop in the tooth. In the mouse, the first tooth represses the formation of the replacement, and isolation of the RSDL is sufficient to induce formation of a new tooth germ. Our data highlight key mechanisms that may have influenced the evolution of replacement teeth. Pracoviště Ústav živočišné fyziologie a genetiky Kontakt Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554 Rok sběru 2021 Elektronická adresa https://dev.biologists.org/content/146/3/dev171363
Počet záznamů: 1