Počet záznamů: 1
VOCALISATION AS A VIABLE ASSESSMENT FOR MINIPIGS TRANSGENIC FOR THE HUNTINGTON GENE?
- 1.
SYSNO ASEP 0498979 Druh ASEP A - Abstrakt Zařazení RIV O - Ostatní Název VOCALISATION AS A VIABLE ASSESSMENT FOR MINIPIGS TRANSGENIC FOR THE HUNTINGTON GENE? Tvůrce(i) Rieke, L. (DE)
Schubert, R. (DE)
Matheis, T. (DE)
Muratori, L. M. (DE)
Freisfeld, F. (DE)
Motlík, Jan (UZFG-Y) RID, ORCID
Fels, M. (DE)
Kemper, N. (DE)
Schuldenzucker, V. (DE)
Reilmann, R. (DE)Zdroj.dok. Journal of Neurology Neurosurgery and Psychiatry - ISSN 0022-3050
Roč. 89, S1 (2018), A23-A23Poč.str. 1 s. Akce Plenary Meeting of the European Huntington´s Disease Network (EHDN) Datum konání 14.09.2018 - 16.09.2018 Místo konání Vienna Země AT - Rakousko Typ akce EUR Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova minipig ; Huntington gene Vědní obor RIV FH - Neurologie, neurochirurgie, neurovědy Obor OECD Neurosciences (including psychophysiology CEP LO1609 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Institucionální podpora UZFG-Y - RVO:67985904 UT WOS 000446126000064 DOI 10.1136/jnnp-2018-EHDN.63 Anotace Backround Large animal models, such as the transgenic (tg) Huntington disease (HD) minipig, have been proposed to improve translational reliability and assessment of safety, efficacy and tolerability in preclinical studies. Minipigs are characterised by high genetic homology and comparable brain structures to humans. In addition, behavioural assessments successfully applied in humans could be explored in minipigs to establish similar endpoints in preclinical and clinical studies. Recently, analysis of voice and speech production was established to characterise HD patients.
Objective The aim of this study was to investigate whether vocalisation could also serve as a viable marker for phenotyping minipigs transgenic for Huntington disease (tgHD) and whether tgHD minipigs reveal changes in this domain compared to wildtype (wt) minipigs.
Methods While conducting behavioural testing, vocalisation incidence was documented for a cohort of 14 tgHD and 18 wt minipigs. Statistical analyses were performed using Fisher’s Exact Test for group comparisons and McNemar’s Test for intra-visit differences between tgHD and wt minipigs.
Results Vocalisation can easily be documented during phenotyping assessments of minipigs. Differences in vocalisation frequency across behavioural conditions were detected between tgHD and wt minipigs. Influence of the genotype on vocalisation was detectable during a period of 1,5 years.
Conclusion Vocalisation may be a viable marker for phenotyping minipigs transgenic for the Huntington gene. Documentation of vocalisation provides a non-invasive opportunity to capture potential disease signs and explore phenotypic development including the age of disease manifestation.
Pracoviště Ústav živočišné fyziologie a genetiky Kontakt Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554 Rok sběru 2019
Počet záznamů: 1