Počet záznamů: 1
Membrane Lipid Nanodomains
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SYSNO ASEP 0498437 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Membrane Lipid Nanodomains Tvůrce(i) Cebecauer, Marek (UFCH-W) RID, ORCID, SAI
Amaro, Mariana (UFCH-W) RID, ORCID
Jurkiewicz, Piotr (UFCH-W) RID, ORCID
Sarmento, Maria Joäo (UFCH-W) ORCID, RID
Šachl, Radek (UFCH-W) RID, ORCID
Cwiklik, Lukasz (UFCH-W) RID, ORCID
Hof, Martin (UFCH-W) RID, ORCIDZdroj.dok. Chemical Reviews. - : American Chemical Society - ISSN 0009-2665
Roč. 118, č. 23 (2018), s. 11259-11297Poč.str. 39 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova membranes ; nanomaterials ; lipids Vědní obor RIV CF - Fyzikální chemie a teoretická chemie Obor OECD Physical chemistry CEP GA17-03160S GA ČR - Grantová agentura ČR Institucionální podpora UFCH-W - RVO:61388955 UT WOS 000453488700001 EID SCOPUS 85056091029 DOI 10.1021/acs.chemrev.8b00322 Anotace Lipid membranes can spontaneously organize their components into domains of different sizes and properties. The organization of membrane lipids into nanodomains might potentially play a role in vital functions of cells and organisms. Model membranes represent attractive systems to study lipid nanodomains, which cannot be directly addressed in living cells with the currently available methods. This review summarizes the knowledge on lipid nanodomains in model membranes and exposes how their specific character contrasts with large-scale phase separation. The overview on lipid nanodomains in membranes composed of diverse lipids (e.g., zwitterionic and anionic glycerophospholipids, ceramides, glycosphingolipids) and cholesterol aims to evidence the impact of chemical, electrostatic, and geometric properties of lipids on nanodomain formation. Furthermore, the effects of curvature, asymmetry, and ions on membrane nanodomains are shown to be highly relevant aspects that may also modulate lipid nanodomains in cellular membranes. Potential mechanisms responsible for the formation and dynamics of nanodomains are discussed with support from available theories and computational studies. A brief description of current fluorescence techniques and analytical tools that enabled progress in lipid nanodomain studies is also included. Further directions are proposed to successfully extend this research to cells. Pracoviště Ústav fyzikální chemie J.Heyrovského Kontakt Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196 Rok sběru 2019
Počet záznamů: 1