Počet záznamů: 1
Comparative genomics of Czech vaccine strains of Bordetella pertussis.
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SYSNO ASEP 0497620 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Comparative genomics of Czech vaccine strains of Bordetella pertussis. Tvůrce(i) Dienstbier, Ana (MBU-M) ORCID
Pouchnik, D. (US)
Wildung, M. (US)
Amman, F. (AT)
Hofacker, I.L. (AT)
Parkhill, J. (AT)
Holubová, Jana (MBU-M) RID, ORCID
Šebo, Peter (MBU-M) RID, ORCID
Večerek, Branislav (MBU-M) RID, ORCIDČíslo článku fty071 Zdroj.dok. Pathogens and Disease - ISSN 2049-632X
Roč. 76, č. 7 (2018)Poč.str. 5 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova Bordetella pertussis ; genome rearrangement ; vaccine pressure Vědní obor RIV EE - Mikrobiologie, virologie Obor OECD Microbiology CEP NV16-30782A GA MZd - Ministerstvo zdravotnictví Institucionální podpora MBU-M - RVO:61388971 UT WOS 000453675500004 EID SCOPUS 85061853892 DOI 10.1093/femspd/fty071 Anotace Bordetella pertussis is a strictly human pathogen causing the respiratory infectious disease called whooping cough or pertussis. B. pertussis adaptation to acellular pertussis vaccine pressure has been repeatedly highlighted, but recent data indicate that adaptation of circulating strains started already in the era of the whole cell pertussis vaccine (wP) use. We sequenced the genomes of five B. pertussis wP vaccine strains isolated in the former Czechoslovakia in the pre-wP (1954–1957) and early wP (1958–1965) eras, when only limited population travel into and out of the country was possible. Four isolates exhibit a similar genome organization and form a distinct phylogenetic cluster with a geographic signature. The fifth strain is rather distinct, both in genome organization and SNP-based phylogeny. Surprisingly, despite isolation of this strain before 1966, its closest sequenced relative appears to be a recent isolate from the US. On the genome content level, the five vaccine strains contained both new and already described regions of difference. One of the new regions contains duplicated genes potentially associated with transport across the membrane. The prevalence of this region in recent isolates indicates that its spread might be associated with selective advantage leading to increased strain fitness. Pracoviště Mikrobiologický ústav Kontakt Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Rok sběru 2019
Počet záznamů: 1