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The defense and signaling role of NADPH oxidases in eukaryotic cells
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SYSNO ASEP 0493879 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název The defense and signaling role of NADPH oxidases in eukaryotic cells Tvůrce(i) Breitenbach, M. (AT)
Rinnerthaler, M. (AT)
Weber, M. (AT)
Breitenbach-Koller, H. (AT)
Karl, T. (AT)
Cullen, P. (US)
Basu, S. (US)
Hašková, Danuša (MBU-M)
Hašek, Jiří (MBU-M) RID, ORCIDZdroj.dok. Wiener Medizinische Wochenschrift. - : Springer - ISSN 0043-5341
Roč. 168, 11-12 (2018), s. 286-299Poč.str. 14 s. Jazyk dok. eng - angličtina Země vyd. AT - Rakousko Klíč. slova Chronic granulomatous disease ; Saccharomyces cerevisiae ; Actin cytoskeleton Vědní obor RIV EE - Mikrobiologie, virologie Obor OECD Microbiology Způsob publikování Open access Institucionální podpora MBU-M - RVO:61388971 UT WOS 000443404100005 EID SCOPUS 85052601158 DOI 10.1007/s10354-018-0640-4 Anotace This short review article summarizes what is known clinically and biochemically about the seven human NADPH oxidases. Emphasis is put on the connection between mutations in the catalytic and regulatory subunits of Nox2, the phagocyte defense enzyme, with syndromes like chronic granulomatous disease, as well as a number of chronic inflammatory diseases. These arise paradoxically from a lack of reactive oxygen species production needed as second messengers for immune regulation. Both Nox2 and the six other human NADPH oxidases display signaling functions in addition to the functions of these enzymes in specialized biochemical reactions, for instance, synthesis of the hormone thyroxine. NADPH oxidases are also needed by Saccharomyces cerevisiae cells for the regulation of the actin cytoskeleton in times of stress or developmental changes, such as pseudohyphae formation. The article shows that in certain cancer cells Nox4 is also involved in the re-structuring of the actin cytoskeleton, which is required for cell mobility and therefore for metastasis. Pracoviště Mikrobiologický ústav Kontakt Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Rok sběru 2019 Elektronická adresa https://link.springer.com/article/10.1007/s10354-018-0640-4
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