Počet záznamů: 1

Localization of RNA and translation in the mammalian oocyte and embryo

SYSNO ASEP	0489565
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Localization of RNA and translation in the mammalian oocyte and embryo
Tvůrce(i)	Jansová, Denisa (UZFG-Y)_ORCID Tětková, Anna (UZFG-Y)_ORCID Končická, Markéta (UZFG-Y)_ORCID Kubelka, Michal (UZFG-Y)_{RID, ORCID} Šušor, Andrej (UZFG-Y)_{RID, ORCID}
Číslo článku	e0192544
Zdroj.dok.	PLoS ONE. - : Public Library of Science - ISSN 1932-6203 Roč. 13, č. 3 (2018)
Poč.str.	15 s.
Forma vydání	Online - E
Jazyk dok.	eng - angličtina
Země vyd.	US - Spojené státy americké
Klíč. slova	RNA localization ; mammalian oocyte
Vědní obor RIV	EB - Genetika a molekulární biologie
Obor OECD	Biochemistry and molecular biology
CEP	GA13-12291S GA ČR - Grantová agentura ČR
	GA15-22765S GA ČR - Grantová agentura ČR
	EF15_003/0000460 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
Institucionální podpora	UZFG-Y - RVO:67985904
UT WOS	000427189300005
EID SCOPUS	85043777411
DOI	10.1371/journal.pone.0192544
Anotace	The tight correlation between mRNA distribution and subsequent protein localization and function indicate a major role for mRNA localization within the cell. RNA localization, followed by local translation, presents a mechanism for spatial and temporal gene expression regulation utilized by various cell types. However, little is known about mRNA localization and translation in the mammalian oocyte and early embryo. Importantly, fully-grown oocyte becomes transcriptionally inactive and only utilizes transcripts previously synthesized and stored during earlier development. We discovered an abundant RNA population in the oocyte and early embryo nucleus together with RNA binding proteins. We also characterized specific ribosomal proteins, which contribute to translation in the oocyte and embryo. By applying selected markers to mouse and human oocytes, we found that there might be a similar mechanism of RNA metabolism in both species. In conclusion, we visualized the localization of RNAs and translation machinery in the oocyte, that could shed light on this terra incognita of these unique cell types in mouse and human.
Pracoviště	Ústav živočišné fyziologie a genetiky
Kontakt	Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554
Rok sběru	2019

Počet záznamů: 1