Počet záznamů: 1

Antibacterial nitric oxide- and singlet oxygen-releasing polystyrene nanoparticles responsive to light and temperature triggers

SYSNO ASEP	0487024
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Antibacterial nitric oxide- and singlet oxygen-releasing polystyrene nanoparticles responsive to light and temperature triggers
Tvůrce(i)	Dolanský, Jiří (UACH-T)_{ORCID, RID, SAI} Henke, P. (CZ) Malá, Z. (CZ) Žárská, L. (CZ) Kubát, Pavel (UFCH-W)_{RID, ORCID, SAI} Mosinger, Jiří (UACH-T)_{RID, ORCID, SAI}
Zdroj.dok.	Nanoscale. - : Royal Society of Chemistry - ISSN 2040-3364 Roč. 10, č. 5 (2018), s. 2639-2648
Poč.str.	10 s.
Jazyk dok.	eng - angličtina
Země vyd.	GB - Velká Británie
Klíč. slova	nanofiber materials ; porphyrin photosensitizers ; photophysical properties ; reactive oxygen
Vědní obor RIV	CA - Anorganická chemie
Obor OECD	Inorganic and nuclear chemistry
Vědní obor RIV – spolupráce	Ústav fyzikální chemie J.Heyrovského - Fyzikální chemie a teoretická chemie
CEP	GA16-15020S GA ČR - Grantová agentura ČR
Institucionální podpora	UACH-T - RVO:61388980 ; UFCH-W - RVO:61388955
UT WOS	000424075400053
EID SCOPUS	85041454084
DOI	10.1039/c7nr08822a
Anotace	Novel therapies to prevent bacterial infections are of utmost importance in biomedical research due to the emergence of multidrug-resistant strains of bacteria. Herein, we report the preparation, characterization and antibacterial evaluation of sulfonated polystyrene nanoparticles simultaneously releasing two antibacterial species, nitric oxide (NO) and singlet oxygen (O-2((1)Delta(g))), upon irradiation with visible light. The nanoparticles were prepared by simple and scalable processes from nanofiber membranes with an encapsulated NO photodonor and/or ionically entangled tetracationic porphyrin/phthalocyanine photosensitizers. The release of NO and O-2((1)Delta(g)) from the polystyrene nanoparticles is controlled by light wavelength and dose, as well as by temperature, which influences the diffusion coefficient and solubility of both species in the polystyrene matrix. The concentrations of NO and O-2((1)Delta(g)) were measured by amperometric and time-resolved spectroscopic techniques and by chemical analysis. Due to the efficient photogeneration of both species at physiological temperature and resultant strong antibacterial action observed on Escherichia coli, the nanoparticles are a promising material for antibacterial applications triggered/modulated by light and temperature.
Pracoviště	Ústav anorganické chemie
Kontakt	Jana Kroneislová, krone@iic.cas.cz, Tel.: 311 236 931
Rok sběru	2019

Počet záznamů: 1