Počet záznamů: 1
Interaction of procyanidin B-3 with membrane lipids Fluorescence, DSC and FTIR studies
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SYSNO ASEP 0476373 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Interaction of procyanidin B-3 with membrane lipids Fluorescence, DSC and FTIR studies Tvůrce(i) Cyboran-Mikolajczyk, S. (PL)
Zylka, R. (PL)
Jurkiewicz, Piotr (UFCH-W) RID, ORCID
Pruchnik, H. (PL)
Oszmianski, J. (PL)
Hof, M. (CZ)
Kleszczynska, H. (PL)Zdroj.dok. Biochimica Et Biophysica Acta-Biomembranes. - : Elsevier - ISSN 0005-2736
Roč. 1859, č. 8 (2017), s. 1362-1371Poč.str. 10 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova FTIR ; Fluidity ; Hydration ; dmpc Vědní obor RIV CF - Fyzikální chemie a teoretická chemie Obor OECD Physical chemistry Institucionální podpora UFCH-W - RVO:61388955 UT WOS 000403520800007 EID SCOPUS 85019174441 DOI 10.1016/j.bbamem.2017.04.026 Anotace Procyanidins, contained in many products abundant in human diet, exhibit high biological activity. However, this activity has not been fully explained at cellular and molecular levels. In this study, we determine the mechanism of interaction of procyanidin B-3 with model lipid membrane. This mechanism was established on the basis of changes induced by B-3 in the physical properties of lipid bilayer. The changes were investigated using steady state and time-resolved fluorescence, DSC, and FTIR. We show that procyanidin B-3 causes changes in the arrangement of the polar heads of lipids, order of their acyl chains and the main lipid phase transition temperature. Furthermore, its presence in the membrane leads to a reduction in membrane dipole potential. Procyanidin B-3 is anchored to membrane via hydrogen bonds formed between its OH groups and the PO2- and C=O groups of lipids, causing changes in both hydrophilic and hydrophobic regions of the membrane. (C) 2017 Published by Elsevier B.V. Pracoviště Ústav fyzikální chemie J.Heyrovského Kontakt Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196 Rok sběru 2018
Počet záznamů: 1