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Cognitive sequelae of methanol poisoning involve executive dysfunction and memory impairment in cross-sectional and long-term perspective
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SYSNO ASEP 0468871 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Cognitive sequelae of methanol poisoning involve executive dysfunction and memory impairment in cross-sectional and long-term perspective Tvůrce(i) Bezdíček, O. (CZ)
Michalec, J. (CZ)
Vaněčková, M. (CZ)
Klempíř, J. (CZ)
Lišková, I. (CZ)
Seidl, Z. (CZ)
Janíková, B. (CZ)
Miovský, M. (CZ)
Hubáček, J. (CZ)
Diblík, P. (CZ)
Kuthan, P. (CZ)
Pilin, A. (CZ)
Kurcová, I. (CZ)
Fenclová, Z. (CZ)
Petřík, V. (CZ)
Navrátil, Tomáš (UFCH-W) RID, ORCID
Pelclová, D. (CZ)
Zakharov, S. (CZ)
Růžička, E. (CZ)Zdroj.dok. Alcohol. - : Elsevier - ISSN 0741-8329
Roč. 59, MAR 2017 (2017), s. 27-35Poč.str. 9 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova methanol poisoning ; cognitive impairment ; memory Vědní obor RIV CF - Fyzikální chemie a teoretická chemie Obor OECD Physical chemistry Institucionální podpora UFCH-W - RVO:61388955 UT WOS 000397359400004 EID SCOPUS 85008951008 DOI 10.1016/j.alcohol.2016.12.003 Anotace Methanol poisoning leads to lesions in the basal ganglia and subcortical white matter, as well as to demyelination and atrophy of the optic nerve. However, information regarding cognitive deficits in a large methanol sample is lacking. The principal aim of the present study was to identify the cognitive sequelae of methanol poisoning and their morphological correlates. A sample of 50 patients (METH, age 48 +/- 13 years), 3-8 months after methanol poisoning, and 57 control subjects (CS, age 49 +/- 13 years) were administered a neuropsychological battery. Forty-six patients were followed in 2 years' perspective. Patients additionally underwent 1.5T magnetic resonance imaging (MRI). Three biochemical and toxicological metabolic markers and a questionnaire regarding alcohol abuse facilitated the classification of 24 patients with methanol poisoning without alcohol abuse (METHna) and 22 patients with methanol poisoning and alcohol abuse (METHa). All groups were compared to a control group of similar size, and matched for age, education, premorbid intelligence level, global cognitive performance, and level of depressive symptoms. Using hierarchical multiple regression we found significant differences between METH and CS, especially in executive and memory domains. METHa showed a similar pattern of cognitive impairment with generally more severe executive dysfunction. Moreover, all METH patients with extensive involvement on brain MRI (lesions in >= 2 anatomical regions) had a more severe cognitive impairment. From a longitudinal perspective, we did not find any changes in their cognitive functioning after 2 years' follow-up. Our findings suggest that methanol poisoning is associated with executive dysfunction and explicit memory impairment, supposedly due to basal ganglia dysfunction and disruption of frontostriatal circuitry proportional to the number of brain lesions, and that these changes are persistent after 2 years' follow-up. Pracoviště Ústav fyzikální chemie J.Heyrovského Kontakt Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196 Rok sběru 2018
Počet záznamů: 1