Polymer-ritonavir derivate nanomedicine with pH-sensitive activation possesses potent anti-tumor activity in vivo via inhibition of proteasome and STAT3 signaling

Sivák, Ladislav; Šubr, Vladimír; Kovářová, Jiřina; Dvořáková, Barbora; Šírová, Milada; Říhová, Blanka; Randárová, Eva; Kraus, Michal; Tomala, Jakub; Studenovský, Martin; Vondráčková, Michaela; Sedláček, Radislav; Makovický, Peter; Fučíková, J.; Vošahlíková, Š.; Spíšek, R.; Kostka, Libor; Etrych, Tomáš; Kovář, Marek

doi:https://dx.doi.org/10.1016/j.jconrel.2021.03.015

Number of the records: 1

Polymer-ritonavir derivate nanomedicine with pH-sensitive activation possesses potent anti-tumor activity in vivo via inhibition of proteasome and STAT3 signaling

1.

SYSNO	0542896
Title	Polymer-ritonavir derivate nanomedicine with pH-sensitive activation possesses potent anti-tumor activity in vivo via inhibition of proteasome and STAT3 signaling
Author(s)	Sivák, Ladislav (MBU-M)_RID Šubr, Vladimír (UMCH-V) [BIOMOL]_{RID, ORCID} Kovářová, Jiřina (MBU-M) Dvořáková, Barbora (MBU-M)_RID Šírová, Milada (MBU-M)_{RID, ORCID} Říhová, Blanka (MBU-M)_RID Randárová, Eva (UMCH-V) [BIOMOL]_{RID, ORCID} Kraus, Michal (MBU-M) Tomala, Jakub (MBU-M)_{RID, ORCID} Studenovský, Martin (UMCH-V) [BIOMOL]_{RID, ORCID} Vondráčková, Michaela (MBU-M) Sedláček, Radislav (UMG-J) [18]_RID Makovický, Peter (UMG-J) [18] Fučíková, J. (CZ) Vošahlíková, Š. (CZ) Spíšek, R. (CZ) Kostka, Libor (UMCH-V) [BIOMOL]_{RID, ORCID} Etrych, Tomáš (UMCH-V) [BIOMOL]_{RID, ORCID} Kovář, Marek (MBU-M)_{RID, ORCID}
Corespondence/senior	Kovář, Marek - Korespondující autor
Source Title	Journal of Controlled Release. Roč. 332, APR 10 2021 (2021), s. 563-580. - : Elsevier
Document Type	Článek v odborném periodiku
Grant	GA19-05649S GA ČR - Czech Science Foundation (CSF), CZ - Czech Republic
	LM2015040 GA MŠMT - Ministry of Education, Youth and Sports (MEYS), CZ - Czech Republic
	ED1.1.00/02.0109 GA MŠMT - Ministry of Education, Youth and Sports (MEYS), CZ - Czech Republic
Institutional support	MBU-M - RVO:61388971 ; UMCH-V - RVO:61389013 ; UMG-J - RVO:68378050
Language	eng
Country	NL
Keywords	Ritonavir derivate * Polymer carrier * pH-controlled release * Antitumor activity * Proteasome inhibition * STAT3 signaling inhibition
Cooperating institutions	Univerzita Karlova v Praze (Czech Republic) Fakultní nemocnice Motol (Czech Republic) Sotio AS, Praha (Czech Republic)
URL	https://www.sciencedirect.com/science/article/pii/S0168365921001267
Permanent Link	http://hdl.handle.net/11104/0320232

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Number of the records: 1