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100 million years of multigene family evolution: origin and evolution of the avian MHC class IIB

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    SYSNO ASEP0475331
    Document TypeJ - Journal Article
    R&D Document TypeJournal Article
    Subsidiary JČlánek ve WOS
    Title100 million years of multigene family evolution: origin and evolution of the avian MHC class IIB
    Author(s) Goebel, J. (CH)
    Promerová, Marta (UBO-W)
    Bonadonna, F. (FR)
    McCoy, K. D. (FR)
    Serbielle, C. (FR)
    Strandh, M. (FR)
    Yannic, G. (FR)
    Burri, R. (DE)
    Fumagalli, L. (CH)
    Number of authors9
    Source TitleBMC Genomics - ISSN 1471-2164
    Roč. 18, č. 460 (2017), s. 1-9
    Number of pages9 s.
    Languageeng - English
    CountryGB - United Kingdom
    KeywordsBirds ; Birth-death evolution ; Concerted evolution ; Gene duplication ; Gene conversion ; Major histocompatibility complex ; Recombination
    Subject RIVEG - Zoology
    OECD categoryGenetics and heredity (medical genetics to be 3)
    R&D ProjectsGAP505/10/1871 GA ČR - Czech Science Foundation (CSF)
    Institutional supportUBO-W - RVO:68081766
    UT WOS000413749900001
    EID SCOPUS85020646288
    DOI10.1186/s12864-017-3839-7
    AnnotationBackground: Gene duplication has led to a most remarkable adaptation involved in vertebrates’ host-pathogen arms-race, the major histocompatibility complex (MHC). However, MHC duplication history is as yet poorly understood in non-mammalian vertebrates, including birds.
    Results: Here, we provide evidence for the evolution of two ancient avian MHC class IIB (MHCIIB) lineages by a duplication event prior to the radiation of all extant birds >100 million years ago, and document the role of concerted evolution in eroding the footprints of the avian MHCIIB duplication history.
    Conclusions: Our results suggest that eroded footprints of gene duplication histories may mimic birth-death evolution and that in the avian MHC the presence of the two lineages may have been masked by elevated rates of concerted evolution in several taxa. Through the presence of a range of intermediate evolutionary stages along the homogenizing process of concerted evolution, the avian MHCIIB provides a remarkable illustration of the erosion of multigene family duplication history.
    WorkplaceInstitute of Vertebrate Biology
    ContactHana Slabáková, slabakova@ivb.cz, Tel.: 543 422 524
    Year of Publishing2018
Number of the records: 1