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100 million years of multigene family evolution: origin and evolution of the avian MHC class IIB

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    0475331 - ÚBO 2018 RIV GB eng J - Journal Article
    Goebel, J. - Promerová, Marta - Bonadonna, F. - McCoy, K. D. - Serbielle, C. - Strandh, M. - Yannic, G. - Burri, R. - Fumagalli, L.
    100 million years of multigene family evolution: origin and evolution of the avian MHC class IIB.
    BMC Genomics. Roč. 18, č. 460 (2017), s. 1-9. ISSN 1471-2164. E-ISSN 1471-2164
    R&D Projects: GA ČR GAP505/10/1871
    Institutional support: RVO:68081766
    Keywords : Birds * Birth-death evolution * Concerted evolution * Gene duplication * Gene conversion * Major histocompatibility complex * Recombination
    OECD category: Genetics and heredity (medical genetics to be 3)
    Impact factor: 3.730, year: 2017

    Background: Gene duplication has led to a most remarkable adaptation involved in vertebrates’ host-pathogen arms-race, the major histocompatibility complex (MHC). However, MHC duplication history is as yet poorly understood in non-mammalian vertebrates, including birds.
    Results: Here, we provide evidence for the evolution of two ancient avian MHC class IIB (MHCIIB) lineages by a duplication event prior to the radiation of all extant birds >100 million years ago, and document the role of concerted evolution in eroding the footprints of the avian MHCIIB duplication history.
    Conclusions: Our results suggest that eroded footprints of gene duplication histories may mimic birth-death evolution and that in the avian MHC the presence of the two lineages may have been masked by elevated rates of concerted evolution in several taxa. Through the presence of a range of intermediate evolutionary stages along the homogenizing process of concerted evolution, the avian MHCIIB provides a remarkable illustration of the erosion of multigene family duplication history.
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