Number of the records: 1
Meis homeobox genes control progenitor competence in the retina
- 1.
SYSNO ASEP 0544817 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Meis homeobox genes control progenitor competence in the retina Author(s) Dupačová, Naoko (UMG-J)
Antošová, Barbora (UMG-J)
Pačes, Jan (UMG-J) RID, ORCID
Kozmik, Zbyněk (UMG-J) RIDNumber of authors 4 Article number e2013136118 Source Title Proceedings of the National Academy of Sciences of the United States of America. - : National Academy of Sciences - ISSN 0027-8424
Roč. 118, č. 12 (2021)Number of pages 12 s. Publication form Online - E Language eng - English Country US - United States Keywords retina ; Meis ; development Subject RIV EB - Genetics ; Molecular Biology OECD category Cell biology R&D Projects GA18-20759S GA ČR - Czech Science Foundation (CSF) LQ1604 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) LM2018126 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) ED2.1.00/19.0395 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) ED1.1.00/02.0109 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Limited access Institutional support UMG-J - RVO:68378050 UT WOS 000631868600012 DOI 10.1073/pnas.2013136118 Annotation The vertebrate eye is derived from the neuroepithelium, surface ectoderm, and extracellular mesenchyme. The neuroepithelium forms an optic cup in which the spatial separation of three domains is established, namely, the region of multipotent retinal progenitor cells (RPCs), the ciliary margin zone (CMZ)-which possesses both a neurogenic and nonneurogenic potential-and the optic disk (OD), the interface between the optic stalk and the neuroretina. Here, we show by genetic ablation in the developing optic cup that Meis1 and Meis2 homeobox genes function redundantly to maintain the retinal progenitor pool while they simultaneously suppress the expression of genes characteristic of CMZ and OD fates. Furthermore, we demonstrate that Meis transcription factors bind regulatory regions of RPC-, CMZ-, and OD-specific genes, thus providing a mechanistic insight into the Meis-dependent gene regulatory network. Our work uncovers the essential role of Meis1 and Meis2 as regulators of cell fate competence, which organize spatial territories in the vertebrate eye. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2022 Electronic address https://www.pnas.org/content/118/12/e2013136118
Number of the records: 1