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Meis homeobox genes control progenitor competence in the retina

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    0544817 - ÚMG 2022 RIV US eng J - Journal Article
    Dupačová, Naoko - Antošová, Barbora - Pačes, Jan - Kozmik, Zbyněk
    Meis homeobox genes control progenitor competence in the retina.
    Proceedings of the National Academy of Sciences of the United States of America. Roč. 118, č. 12 (2021), č. článku e2013136118. ISSN 0027-8424
    R&D Projects: GA ČR(CZ) GA18-20759S; GA MŠk(CZ) LQ1604; GA MŠk(CZ) LM2018126; GA MŠk ED2.1.00/19.0395; GA MŠk(CZ) ED1.1.00/02.0109
    Institutional support: RVO:68378050
    Keywords : retina * Meis * development
    OECD category: Cell biology
    Impact factor: 12.779, year: 2021
    Method of publishing: Limited access
    https://www.pnas.org/content/118/12/e2013136118

    The vertebrate eye is derived from the neuroepithelium, surface ectoderm, and extracellular mesenchyme. The neuroepithelium forms an optic cup in which the spatial separation of three domains is established, namely, the region of multipotent retinal progenitor cells (RPCs), the ciliary margin zone (CMZ)-which possesses both a neurogenic and nonneurogenic potential-and the optic disk (OD), the interface between the optic stalk and the neuroretina. Here, we show by genetic ablation in the developing optic cup that Meis1 and Meis2 homeobox genes function redundantly to maintain the retinal progenitor pool while they simultaneously suppress the expression of genes characteristic of CMZ and OD fates. Furthermore, we demonstrate that Meis transcription factors bind regulatory regions of RPC-, CMZ-, and OD-specific genes, thus providing a mechanistic insight into the Meis-dependent gene regulatory network. Our work uncovers the essential role of Meis1 and Meis2 as regulators of cell fate competence, which organize spatial territories in the vertebrate eye.
    Permanent Link: http://hdl.handle.net/11104/0321624

     
     
Number of the records: 1