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No evidence for accumulation of deleterious mutations and fitness degradation in clonal fish hybrids: Abandoning sex without regrets
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SYSNO ASEP 0531707 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title No evidence for accumulation of deleterious mutations and fitness degradation in clonal fish hybrids: Abandoning sex without regrets Author(s) Kočí, Jan (UZFG-Y)
Röslein, Jan (UZFG-Y)
Pačes, Jan (UZFG-Y)
Kotusz, J. (PL)
Halačka, Karel (UBO-W) RID, SAI
Koščo, J. (SK)
Fedorčák, J. (SK)
Iakovenko, Nataliia (UZFG-Y) ORCID
Janko, Karel (UZFG-Y) RID, ORCIDSource Title Molecular Ecology. - : Wiley - ISSN 0962-1083
Roč. 29, č. 16 (2020), s. 3038-3055Number of pages 18 s. Publication form Print - P Language eng - English Country GB - United Kingdom Keywords asexuality ; clonal decay ; exome capture ; fitness ; Muller´s ratchet ; mutation load Subject RIV EB - Genetics ; Molecular Biology OECD category Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology Subject RIV - cooperation Institute of Vertebrate Biology - Ecology, Behaviour R&D Projects GA13-12580S GA ČR - Czech Science Foundation (CSF) LM2015047 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) EF15_003/0000460 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support UZFG-Y - RVO:67985904 ; UBO-W - RVO:68081766 UT WOS 000555275600001 EID SCOPUS 85088860889 DOI 10.1111/mec.15539 Annotation Despite its inherent costs, sexual reproduction is ubiquitous in nature, and the mechanisms to protect it from a competitive displacement by asexuality remain unclear. Popular mutation-based explanations, like the Muller's ratchet and the Kondrashov's hatchet, assume that purifying selection may not halt the accumulation of deleterious mutations in the nonrecombining genomes, ultimately leading to their degeneration. However, empirical evidence is scarce and it remains particularly unclear whether mutational degradation proceeds fast enough to ensure the decay of clonal organisms and to prevent them from outcompeting their sexual counterparts. To test this hypothesis, we jointly analysed the exome sequences and the fitness-related phenotypic traits of the sexually reproducing fish species and their clonal hybrids, whose evolutionary ages ranged from F1 generations to 300 ky. As expected, mutations tended to accumulate in the clonal genomes in a time-dependent manner. However, contrary to the predictions, we found no trend towards increased nonsynonymity of mutations acquired by clones, nor higher radicality of their amino acid substitutions. Moreover, there was no evidence for fitness degeneration in the old clones compared with that in the younger ones. In summary, although an efficacy of purifying selection may still be reduced in the asexual genomes, our data indicate that its efficiency is not drastically decreased. Even the oldest investigated clone was found to be too young to suffer fitness consequences from a mutation accumulation. This suggests that mechanisms other than mutation accumulation may be needed to explain the competitive advantage of sex in the short term. Workplace Institute of Animal Physiology and Genetics Contact Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554 Year of Publishing 2021 Electronic address https://onlinelibrary.wiley.com/doi/full/10.1111/mec.15539?af=R
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