Number of the records: 1
Structure degradation and strength changes of sintered calcium phosphate bone scaffolds with different phase structures during simulated biodegradation in vitro
- 1.
SYSNO ASEP 0511559 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Structure degradation and strength changes of sintered calcium phosphate bone scaffolds with different phase structures during simulated biodegradation in vitro Author(s) Šťastný, P. (CZ)
Sedláček, R. (CZ)
Suchý, Tomáš (USMH-B) RID, ORCID, SAI
Lukášová, Věra (UEM-P)
Rampichová, Michala (UEM-P) RID, ORCID
Trunec, M. (CZ)Source Title Materials Science & Engineering C-Materials for Biological Applications. - : Elsevier - ISSN 0928-4931
Roč. 100, JUL 2019 (2019), s. 544-553Number of pages 10 s. Publication form Print - P Language eng - English Country NL - Netherlands Keywords Scaffold ; Calcium phosphate ; Phase composition ; Degradation ; Compressive strength ; Cell response Subject RIV JH - Ceramics, Fire-Resistant Materials and Glass OECD category Medical engineering Subject RIV - cooperation Institute of Experimental Medicine - Biotechnology ; Bionics R&D Projects GA18-09306S GA ČR - Czech Science Foundation (CSF) GA16-14758S GA ČR - Czech Science Foundation (CSF) Method of publishing Limited access Institutional support USMH-B - RVO:67985891 ; UEM-P - RVO:68378041 UT WOS 000466059700053 EID SCOPUS 85062829153 DOI 10.1016/j.msec.2019.03.027 Annotation The structure degradation and strength changes of calcium phosphate scaffolds after long-term exposure to an acidic environment simulating the osteoclastic activity were determined and compared. Sintered calcium phosphate scaffolds with different phase structures were prepared with a similar cellular pore structure and an open porosity of over 80%. Due to microstructural features the biphasic calcium phosphate (BCP) scaffolds had a higher compressive strength of 1.7 MPa compared with the hydroxyapatite (HA) and beta-tricalcium phosphate (TCP) scaffolds, which exhibited a similar strength of 1.2 MPa. After exposure to an acidic buffer solution of pH = 5.5, the strength of the HA scaffolds did not change over 14 days. On the other hand, the strength of the TCP scaffolds decreased steeply in the first 2 days and reached a negligible value of 0.09 MPa after 14 days. The strength of the BCP scaffolds showed a steady decrease with a reasonable value of 0.5 MPa after 14 days. The mass loss, phase composition and microstructural changes of the scaffolds during degradation in the acidic environment were investigated and a mechanism of scaffold degradation was proposed. The BCP scaffold showed the best cell response in the in vitro tests. The BCP scaffold structure with the highly soluble phase (alpha-TCP) embedded in a less soluble matrix (beta-TCP/HA) exhibited a controllable degradation with a suitable strength stability and with beneficial biological behavior it represented the preferred calcium phosphate structure for a resorbable bone scaffold. Workplace Institute of Rock Structure and Mechanics Contact Iva Švihálková, svihalkova@irsm.cas.cz, Tel.: 266 009 216 Year of Publishing 2020 Electronic address https://www.sciencedirect.com/science/article/pii/S0928493118339717?via%3Dihub
Number of the records: 1