Structure degradation and strength changes of sintered calcium phosphate bone scaffolds with different phase structures during simulated biodegradation in vitro

0511559 - ÚSMH 2020 RIV NL eng J - Journal Article
Šťastný, P. - Sedláček, R. - Suchý, Tomáš - Lukášová, Věra - Rampichová, Michala - Trunec, M.
Structure degradation and strength changes of sintered calcium phosphate bone scaffolds with different phase structures during simulated biodegradation in vitro.
Materials Science & Engineering C-Materials for Biological Applications. Roč. 100, JUL 2019 (2019), s. 544-553. ISSN 0928-4931. E-ISSN 1873-0191
R&D Projects: GA ČR(CZ) GA18-09306S; GA ČR(CZ) GA16-14758S
Institutional support: RVO:67985891 ; RVO:68378041
Keywords : Scaffold * Calcium phosphate * Phase composition * Degradation * Compressive strength * Cell response
OECD category: Medical engineering; Biomaterials (as related to medical implants, devices, sensors) (UEM-P)
Impact factor: 5.880, year: 2019
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/pii/S0928493118339717?via%3Dihub

The structure degradation and strength changes of calcium phosphate scaffolds after long-term exposure to an acidic environment simulating the osteoclastic activity were determined and compared. Sintered calcium phosphate scaffolds with different phase structures were prepared with a similar cellular pore structure and an open porosity of over 80%. Due to microstructural features the biphasic calcium phosphate (BCP) scaffolds had a higher compressive strength of 1.7 MPa compared with the hydroxyapatite (HA) and beta-tricalcium phosphate (TCP) scaffolds, which exhibited a similar strength of 1.2 MPa. After exposure to an acidic buffer solution of pH = 5.5, the strength of the HA scaffolds did not change over 14 days. On the other hand, the strength of the TCP scaffolds decreased steeply in the first 2 days and reached a negligible value of 0.09 MPa after 14 days. The strength of the BCP scaffolds showed a steady decrease with a reasonable value of 0.5 MPa after 14 days. The mass loss, phase composition and microstructural changes of the scaffolds during degradation in the acidic environment were investigated and a mechanism of scaffold degradation was proposed. The BCP scaffold showed the best cell response in the in vitro tests. The BCP scaffold structure with the highly soluble phase (alpha-TCP) embedded in a less soluble matrix (beta-TCP/HA) exhibited a controllable degradation with a suitable strength stability and with beneficial biological behavior it represented the preferred calcium phosphate structure for a resorbable bone scaffold.
Permanent Link: http://hdl.handle.net/11104/0301803