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Pervaporation of (R)/(S)-Methyl 3-Hydroxybutyrate (∑MHB) from a Mixture Containing an Ionic Liquid, Methanol and Ru Catalyst.

SYSNO ASEP	0503819
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Pervaporation of (R)/(S)-Methyl 3-Hydroxybutyrate (∑MHB) from a Mixture Containing an Ionic Liquid, Methanol and Ru Catalyst.
Author(s)	Gaálová, Jana (UCHP-M)_{RID, SAI, ORCID} Hejda, Stanislav (UCHP-M)_{RID, ORCID, SAI} Stavárek, Petr (UCHP-M)_{RID, ORCID, SAI} Sýkora, Jan (UCHP-M)_{RID, ORCID, SAI} Fajgar, Radek (UCHP-M)_{RID, ORCID, SAI} Klusoň, Petr (UCHP-M)_{RID, ORCID, SAI} Izák, Pavel (UCHP-M)_{RID, ORCID, SAI}
Source Title	Separation and Purification Technology. - : Elsevier - ISSN 1383-5866 Roč. 222, SEP 1 (2019), s. 45-52
Number of pages	8 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	methyl 3 - hydroxybutyrate ; pervaporation ; ionic liquid
Subject RIV	CI - Industrial Chemistry, Chemical Engineering
OECD category	Chemical process engineering
R&D Projects	GA17-00089S GA ČR - Czech Science Foundation (CSF)
Method of publishing	Limited access
Institutional support	UCHP-M - RVO:67985858
UT WOS	000468714100006
EID SCOPUS	85064075206
DOI	10.1016/j.seppur.2019.04.017
Annotation	Complex technologies in the production of fine chemicals bring together various connected processes, each bringing specific green chemistry challenges. A valuable mixture arises in the stereoselective hydrogenation of methyl-acetoacetate (MAA) to (R)- and (S)- methyl 3-hydroxybutyrate (∑MHB) over Ru organometallic complex (R)-Ru/BINAP, and in a green tetra-alkylammonium bistriflimide/methanol/water solvent phase. The reaction could be carried out in various arrangements, e.g. in a batch mode, in a continuous stirred-tank reactor, or even in a tubular microfluidic chip reactor. In either case, the valuable optically pure Ru complex has been sought to be effectively separated, and potentially recycled. The ionic liquid phase (tetra-alkylammonium bistriflimide) is intended for selective accommodation of the complex in the reaction mixture and as a green alternative to other solvents. It was the main issue of this work to design a specific separation unit, to construct it, and to optimize its performance towards the efficient separation of ∑MHB from the ionic liquid phase bearing the (R)-Ru/BINAP complex. The unit was developed to be connected with the complex preparation process, employing the microreactor fluid flow platform. The separation part of the overall technology was designed as a membrane pervaporation. The membrane separation proceeded with different feed mixtures combining ∑methyl 3-hydroxybutyrate, methanol, ionic liquid and/or the catalyst. The technique was applied at various temperatures, using the industrial composite PDMS membrane, PERVAP™ 4060 from Sulzer. The feed as well as the pervaporate were analyzed by nuclear magnetic resonance spectroscopy and infrared spectroscopy. The enrichment factor of the ∑MHB with respect to the retentate was 1.24 and the ∑MHB permeate mass flux was 61 g h −1 m −2 . In addition, the membrane was characterized by scanning electron microscopy and energy dispersive X-ray microanalysis after the membrane process, showing no sorption of the catalyst into the membrane.
Workplace	Institute of Chemical Process Fundamentals
Contact	Eva Jirsová, jirsova@icpf.cas.cz, Tel.: 220 390 227
Year of Publishing	2020
Electronic address	http://hdl.handle.net/11104/0295889

Number of the records: 1