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Supramolecular structures and self-association processes in polymer systems
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SYSNO ASEP 0463568 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Supramolecular structures and self-association processes in polymer systems Author(s) Hrubý, Martin (UMCH-V) RID, ORCID
Filippov, Sergey K. (UMCH-V) RID, ORCID, SAI
Štěpánek, Petr (UMCH-V) RID, ORCIDSource Title Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408
Roč. 65, Suppl. 2 (2016), S165-S178Number of pages 14 s. Language eng - English Country CZ - Czech Republic Keywords copolymers ; nanoparticles ; phase separation Subject RIV CD - Macromolecular Chemistry R&D Projects LO1507 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support UMCH-V - RVO:61389013 UT WOS 000386686800003 EID SCOPUS 84997402802 Annotation Self-organization in a polymer system appears when a balance is achieved between long-range repulsive and short-range attractive forces between the chemically different building blocks. Block copolymers forming supramolecular assemblies in aqueous media represent materials which are extremely useful for the construction of drug delivery systems especially for cancer applications. Such formulations suppress unwanted physico-chemical properties of the encapsulated drugs, modify biodistribution of the drugs towards targeted delivery into tissue of interest and allow triggered release of the active cargo. In this review, we focus on general principles of polymer self-organization in solution, phase separation in polymer systems (driven by external stimuli, especially by changes in temperature, pH, solvent change and light) and on effects of copolymer architecture on the self-assembly process. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2017 Electronic address http://www.biomed.cas.cz/physiolres/pdf/65%20Suppl%202/65_S165.pdf
Number of the records: 1