Supramolecular structures and self-association processes in polymer systems

0463568 - ÚMCH 2017 RIV CZ eng J - Journal Article
Hrubý, Martin - Filippov, Sergey K. - Štěpánek, Petr
Supramolecular structures and self-association processes in polymer systems.
Physiological Research. Roč. 65, Suppl. 2 (2016), S165-S178. ISSN 0862-8408. E-ISSN 1802-9973
R&D Projects: GA MŠMT(CZ) LO1507
Institutional support: RVO:61389013
Keywords : copolymers * nanoparticles * phase separation
Subject RIV: CD - Macromolecular Chemistry
Impact factor: 1.461, year: 2016
http://www.biomed.cas.cz/physiolres/pdf/65%20Suppl%202/65_S165.pdf

Self-organization in a polymer system appears when a balance is achieved between long-range repulsive and short-range attractive forces between the chemically different building blocks. Block copolymers forming supramolecular assemblies in aqueous media represent materials which are extremely useful for the construction of drug delivery systems especially for cancer applications. Such formulations suppress unwanted physico-chemical properties of the encapsulated drugs, modify biodistribution of the drugs towards targeted delivery into tissue of interest and allow triggered release of the active cargo. In this review, we focus on general principles of polymer self-organization in solution, phase separation in polymer systems (driven by external stimuli, especially by changes in temperature, pH, solvent change and light) and on effects of copolymer architecture on the self-assembly process.
Permanent Link: http://hdl.handle.net/11104/0264455