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Planar Functionalized Surfaces for Direct Immunoaffinity Desorption/Ionization Mass Spectrometry
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SYSNO ASEP 0460136 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Planar Functionalized Surfaces for Direct Immunoaffinity Desorption/Ionization Mass Spectrometry Author(s) Pompach, Petr (MBU-M) RID, ORCID
Kavan, Daniel (MBU-M) RID, ORCID
Benada, Oldřich (MBU-M) ORCID, RID
Růžička, V. (CZ)
Volný, M. (CZ)
Novák, Petr (MBU-M) RID, ORCIDSource Title Clinical Chemistry. - : Oxford University Press - ISSN 0009-9147
Roč. 62, č. 1 (2016), s. 270-278Number of pages 9 s. Language eng - English Country US - United States Keywords TREATED METAL-SURFACE ; IN-SITU ENRICHMENT ; ELECTROSPRAY DEPOSITION Subject RIV CE - Biochemistry R&D Projects LO1509 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) EE2.3.30.0003 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) ED1.1.00/02.0109 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support MBU-M - RVO:61388971 UT WOS 000367703400036 EID SCOPUS 84954552992 DOI 10.1373/clinchem.2015.244004 Annotation Recent studies show that the haptoglobin phenotype in individuals with diabetes mellitus is an important factor for predicting the risk of myocardial infarction, cardiovascular death, and stroke. Current methods for haptoglobin phenotyping include PCR and gel electrophoresis. A need exists for a reliable method for high-throughput clinical applications. Mass spectrometry (MS) can in principle provide fast phenotyping because haptoglobin a 1 and a 2, which define the phenotype, have different molecular masses. Because of the complexity of the serum matrix, an efficient and fast enrichment technique is necessary for an MS-based assay. Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2017
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