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Cryptosporidium tyzzeri and Cryptosporidium muris originated from wild West-European house mice (Mus musculus domesticus) and East-European house mice (Mus musculus musculus) are non-infectious for pigs
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SYSNO ASEP 0377249 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Cryptosporidium tyzzeri and Cryptosporidium muris originated from wild West-European house mice (Mus musculus domesticus) and East-European house mice (Mus musculus musculus) are non-infectious for pigs Author(s) Kváč, Martin (BC-A) RID, RID, ORCID
Kestřánová, M. (CZ)
Květoňová, Dana (BC-A) SAI
Kotková, M. (CZ)
Ortega, Y. (US)
McEvoy, J. (US)
Sak, Bohumil (BC-A) RID, ORCIDSource Title Experimental Parasitology. - : Elsevier - ISSN 0014-4894
Roč. 131, č. 1 (2012), s. 107-110Number of pages 4 s. Language eng - English Country US - United States Keywords Pigs ; Cryptosporidium tyzzeri ; Cryptosporidium muris ; Experimental infection ; PCR ; Histology Subject RIV GJ - Animal Vermins ; Diseases, Veterinary Medicine R&D Projects LH11061 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support BC-A - RVO:60077344 UT WOS 000303956100018 DOI https://doi.org/10.1016/j.exppara.2012.03.016 Annotation Three and 8 week old pigs were inoculated with Cryptosporidium muris HZ206 (Mus musculus musculus isolate), Cryptosporidium tyzerri CR2090 (M. m. musculus isolate) or C. tyzzeri CR4293 (isolate from a hybrid between Mus musculus domesticus and M. m. musculus) at a dose of 1 _ 107 oocysts per animal. Inoculated pigs showed no detectable infection and no clinical symptoms of cryptosporidiosis during 30 days post infection (DPI), and no macroscopic changes were detected in the digestive tract following necropsy. Developmental stages were not detected in gastrointestinal tract tissue by histology or PCR throughout the duration of the experiment. The infectivity of isolates was verified on SCID mice, in which oocysts shedding started from 4 to 8 DPI. Based on our findings, it can be concluded that pigs are not susceptible to C. muris or C. tyzzeri infection. Workplace Biology Centre (since 2006) Contact Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Year of Publishing 2013 Electronic address http://www.sciencedirect.com/science/article/pii/S0014489412001105
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