Cryptosporidium tyzzeri and Cryptosporidium muris originated from wild West-European house mice (Mus musculus domesticus) and East-European house mice (Mus musculus musculus) are non-infectious for pigs

0377249 - BC 2013 RIV US eng J - Journal Article
Kváč, Martin - Kestřánová, M. - Květoňová, Dana - Kotková, M. - Ortega, Y. - McEvoy, J. - Sak, Bohumil
Cryptosporidium tyzzeri and Cryptosporidium muris originated from wild West-European house mice (Mus musculus domesticus) and East-European house mice (Mus musculus musculus) are non-infectious for pigs.
Experimental Parasitology. Roč. 131, č. 1 (2012), s. 107-110. ISSN 0014-4894. E-ISSN 1090-2449
R&D Projects: GA MŠMT(CZ) LH11061
Grant - others:GA ČR(CZ) GA206/08/0640
Program: GA
Institutional support: RVO:60077344
Keywords : Pigs * Cryptosporidium tyzzeri * Cryptosporidium muris * Experimental infection * PCR * Histology
Subject RIV: GJ - Animal Vermins ; Diseases, Veterinary Medicine
Impact factor: 2.154, year: 2012
http://www.sciencedirect.com/science/article/pii/S0014489412001105

Three and 8 week old pigs were inoculated with Cryptosporidium muris HZ206 (Mus musculus musculus isolate), Cryptosporidium tyzerri CR2090 (M. m. musculus isolate) or C. tyzzeri CR4293 (isolate from a hybrid between Mus musculus domesticus and M. m. musculus) at a dose of 1 _ 107 oocysts per animal. Inoculated pigs showed no detectable infection and no clinical symptoms of cryptosporidiosis during 30 days post infection (DPI), and no macroscopic changes were detected in the digestive tract following necropsy. Developmental stages were not detected in gastrointestinal tract tissue by histology or PCR throughout the duration of the experiment. The infectivity of isolates was verified on SCID mice, in which oocysts shedding started from 4 to 8 DPI. Based on our findings, it can be concluded that pigs are not susceptible to C. muris or C. tyzzeri infection.
Permanent Link: http://hdl.handle.net/11104/0209457